TTK21 is an activator of the histone acetyltransferases CBP/p300. TTK21 can cross the blood-brain barrier, and reaches different parts of the brain when conjugated to glucose-based carbon nanosphere (CSP). TTK21 induces acetylation of histones H3 and H4 but not H2B and H2A in vitro.
TTK21 promotes neurogenesis and prolongs memory duration in adult mice, sensory regeneration and germination of motor axons, and recovery of sensory and motor function in mouse and rat models of spinal cord injury. TTK21 has potential for research of brain neurogenesis and long-term memory function.
| Molecular Weight | 357.75 |
| Formula | C17H15ClF3NO2 |
| CAS Number | 709676-56-2 |
| Form | Solid |
| Solubility (25°C) | DMSO 80 mg/mL (ultrasonic and warming) |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
| Related Histone Acetyltransferase Products |
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AU-18069 is a CBP/p300 HAT inhibitor that can be used in studies related to hematological and solid tumors. |
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KAT modulator-1 is a KAT modulator. |
| KAT6-IN-1
KAT6-IN-1 is a potent KAT6 inhibitor. |
| MC4171
MC4171 is a selective KAT8 inhibitor (IC50=8.1 µM). |
| MOZ-IN-3
MOZ-IN-3 is a KAT6A (MOZ) acetyltransferase inhibitor (IC50: 30 nM). |
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