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Cat. No. M25562
TTK21 Structure


Size Price Availability Quantity
5mg USD 160  USD160 In stock
10mg USD 240  USD240 In stock
25mg USD 440  USD440 In stock
50mg USD 700  USD700 In stock
100mg USD 1080  USD1080 In stock
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Quality Control & Documentation
Biological Activity

TTK21 is an activator of the histone acetyltransferases CBP/p300. TTK21 can cross the blood-brain barrier, and reaches different parts of the brain when conjugated to glucose-based carbon nanosphere (CSP). TTK21 induces acetylation of histones H3 and H4 but not H2B and H2A in vitro.

TTK21 promotes neurogenesis and prolongs memory duration in adult mice, sensory regeneration and germination of motor axons, and recovery of sensory and motor function in mouse and rat models of spinal cord injury. TTK21 has potential for research of brain neurogenesis and long-term memory function.

Chemical Information
Molecular Weight 357.75
Formula C17H15ClF3NO2
CAS Number 709676-56-2
Form Solid
Solubility (25°C) DMSO 80 mg/mL (ultrasonic and warming)
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.


[1] Franziska Müller, et al. PLoS Biol. CBP/p300 activation promotes axon growth, sprouting, and synaptic plasticity in chronic experimental spinal cord injury with severe disability

[2] Akash K Singh, et al. Aging Cell. Glucose derived carbon nanosphere (CSP) conjugated TTK21, an activator of the histone acetyltransferases CBP/p300, ameliorates amyloid-beta 1-42 induced deficits in plasticity and associativity in hippocampal CA1 pyramidal neurons

[3] Thomas H Hutson, et al. Sci Transl Med. Cbp-dependent histone acetylation mediates axon regeneration induced by environmental enrichment in rodent spinal cord injury models

[4] Snehajyoti Chatterjee, et al. EMBO Mol Med. Reinstating plasticity and memory in a tauopathy mouse model with an acetyltransferase activator

[5] Snehajyoti Chatterjee, et al. J Neurosci. A novel activator of CBP/p300 acetyltransferases promotes neurogenesis and extends memory duration in adult mice

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Keywords: TTK21, TTK-21 supplier, Histone Acetyltransferase, inhibitors, activators

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