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Histone Acetyltransferase Histone Acetyltransferase

Cat.No.  Name Information
M3645 MG149 MG149 is a selective and potent Tip60 inhibitor with IC50 of 74 uM, similar potentcy for MOF (IC50= 47 uM); little potent for PCAF and p300 (IC50 >200 uM).
M2198 Curcumin Curcumin (Diferuloyl), a natural phenolic compound, is a p300/CREB binding protein specific inhibitor that inhibits histone/non-histone acetylation and histone acetyltransferase-dependent chromatin transcription. Curcumin inhibited NF-κ B and MAPKs, and had anti-inflammatory, antioxidant, anti-proliferation and anti-angiogenesis effects. Curcumin induces Nrf2 protein stabilization through Keap1 cysteine modification.
M40815 PF-9363 PF-9363 is a first-in-class, orally active, highly selective KAT6A/B inhibitor for studies related to ER-positive breast cancer.
M28625 PU139  PU139 is a potent pan-histone acetyltransferase (HAT) inhibitor. PU139 blocks the HATs Gcn5, p300/CBP-associated factor (PCAF), CREB (cAMP response element-binding) protein (CBP) and p300 with IC50s of 8.39, 9.74, 2.49 and 5.35 μM, respectively.
M25562 TTK21 TTK21 is an activator of the histone acetyltransferases CBP/p300. TTK21 can cross the blood-brain barrier, and reaches different parts of the brain when conjugated to glucose-based carbon nanosphere (CSP). TTK21 has potential for research of brain neurogenesis and long-term memory function.
M25561 CTB CTB is a potent p300 histone acetyltransferase activator. CTB induces time dependence apoptosis of MCF-7 cells.
M13828 CTPB CTPB is a good activator of p300 histone acetyl transferase (HAT) enzyme.
M13827 Butyrolactone 3 Butyrolactone 3 (MB-3) is a specifical small-molecule inhibitor of the histone acetyltransferase Gcn5 (IC50=100 μM), which has a high affinity to the Gcn5 enzyme comparable to that of its natural substrate, histone H3.
M11175 WM-3835 WM-3835 is a potent, highly specific HBO1 (KAT7 or MYST2) inhibitor that binds directly to the acetyl-Coenzyme A binding site of HBO1 33 and WM-3835 activates apoptosis while inhibiting proliferation, migration, and invasion of osteosarcoma (OS) cells. WM-3835 has anti-tumor activity and effectively inhibits the growth of osteosarcoma xenografts in mice.
M10585 WM-1119 WM-1119 is a highly potent, selective inhibitor of lysine acetyltransferase KAT6A with IC50 of 0.25 μM, Kd of 2 nM, WM-1119 is a reversible competitor of acetyl coenzyme A and inhibits MYST-catalysed histone acetylation.
M9919 TH1834 TH1834 is a specific Tip60 (KAT5) histone acetyltransferase (HAT) inhibitor.
M9561 A-485 A-485 is a potent and selective HAT inhibitor of p300/CBP in vitro with an IC50 of 10 nM in a p300 TR-FRET assay and 3 nM in a CBP TR-FRET assay with selectivity > 1000-fold over closely related HATs.
M9469 WM-8014 WM-8014, also known as MOZ-IN-3, is a highly potent inhibitor of MOZ with an IC50 of 55 nM.
M9445 YF2 YF2 is a selective HAT (histone acetyltransferase) activator, with EC50 values of 2.75 μM, 29.04 μM and 49.31 μM for CBP, PCAF and GCN5, respectively.
M9410 Remodelin hydrobromide Remodelin hydrobromide is a novel potent and selective inhibitor of the acetyl-transferase protein NAT10.
M7738 CPTH2 CPTH2 is a histone acetyltransferase (HAT) inhibitor modulating the Gcn5 network.
M7065 NU 9056 NU 9056 is a inhibitor of KAT5 (Tip60).
M6808 I-CBP 112 I-CBP 112 is a selective CBP/p300 BRD inhibitor.
M5312 Anacardic Acid Anacardic Acid is a potent inhibitor of p300 and p300/CBP-associated factor histone acetyltranferases, which also has antibacterial activity, antimicrobial activity, prostaglandin synthase inhibition, and tyrosinase and lipoxygenase inhibition.
M4898 Histone Acetyltransferase Inhibitor II Histone Acetyltransferase Inhibitor II, insulin producing cells capable of secreting blood glucose regulating hormones, specially insulin, in response to physiological signals, method of production of said cells and uses thereof.




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