CTB is a potent p300 histone acetyltransferase activator.
CTB (10, 50, 100, 150, 200, and 250 µM; 10 min) enhances p300 HAT activity of p300 in a dosedependent manner. CTB (50 uM; 24 h) increases p300/CBP activity , and reduces autophagic flux in primary neurons.
CTB induces time dependence apoptosis of MCF-7 cells.
|Solubility (25°C)||DMSO 90 mg/mL|
|Storage||4°C, protect from light|
|Body Surface Area (m2)||0.007||0.025||0.15||0.05||0.02||0.5|
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|
|Animal A Km|
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
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