CTB is a potent p300 histone acetyltransferase activator.
CTB (10, 50, 100, 150, 200, and 250 µM; 10 min) enhances p300 HAT activity of p300 in a dosedependent manner. CTB (50 uM; 24 h) increases p300/CBP activity , and reduces autophagic flux in primary neurons.
CTB induces time dependence apoptosis of MCF-7 cells.
| Molecular Weight | 343.73 |
| Formula | C16H13ClF3NO2 |
| CAS Number | 451491-47-7 |
| Form | Solid |
| Solubility (25°C) | DMSO 90 mg/mL |
| Storage | 4°C, protect from light |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
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| DCH36_06
DCH36_06 is a potent and selective p300/CBP inhibitor with IC50s of 0.6 μM and 3.2 μM for p300 and CBP, respectively. DCH36_06 mediated p300/CBP inhibition leading to hypoacetylation on H3K18 in leukemic cells. Anti-tumor activity. |
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