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Cat. No. M25561
CTB Structure
Size Price Availability Quantity
5mg USD 80  USD80 In stock
10mg USD 120  USD120 In stock
25mg USD 250  USD250 In stock
50mg USD 400  USD400 In stock
100mg USD 640  USD640 In stock
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Quality Control & Documentation
Biological Activity

CTB is a potent p300 histone acetyltransferase activator.

CTB (10, 50, 100, 150, 200, and 250 µM; 10 min) enhances p300 HAT activity of p300 in a dosedependent manner. CTB (50 uM; 24 h) increases p300/CBP activity , and reduces autophagic flux in primary neurons.

CTB induces time dependence apoptosis of MCF-7 cells.

Chemical Information
Molecular Weight 343.73
Formula C16H13ClF3NO2
CAS Number 451491-47-7
Form Solid
Solubility (25°C) DMSO 90 mg/mL
Storage 4°C, protect from light
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.


[1] Shuhua Zhang, et al. J Hepatocell Carcinoma. CTB-193M12.5 Promotes Hepatocellular Carcinoma Progression via Enhancing NSD1-Mediated WNT10B/Wnt/β-Catenin Signaling Activation

[2] Yoshikazu Yuki, et al. Lancet Microbe. Oral MucoRice-CTB vaccine for safety and microbiota-dependent immunogenicity in humans: a phase 1 randomised trial

[3] Yoshikazu Yuki, et al. Vaccine. Oral MucoRice-CTB vaccine is safe and immunogenic in healthy US adults

[4] Xiaoying Zhang, et al. Pharmaceutics. Evaluation of CTB-sLip for Targeting Lung Metastasis of Colorectal Cancer

[5] Xiaobing Peng, et al. J Vet Med Sci. Recombinant unpurified rETXH106P/ CTB-rETXY196E protects rabbits against Clostridium perfringens epsilon toxin

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Keywords: CTB supplier, Histone Acetyltransferase, inhibitors, activators

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