Free shipping on all orders over $ 500

CTPB

Cat. No. M13828
CTPB Structure
Size Price Availability
5mg USD 330  USD330 4-7 Days
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

CTPB is a good activator of p300 histone acetyl transferase (HAT) enzyme.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 554.13
Formula
CAS Number 586976-24-1
Purity >99%
Solubility DMSO 62.5 mg/mL
Storage at -20°C
References

[1] Oliver Shey-Njila, et al. Int J Mol Sci. CtpB Facilitates Mycobacterium tuberculosis Growth in Copper-Limited Niches

[2] Lei Li, et al. J Cancer Res Ther. Benign pathologies results from lung nodule percutaneous biopsies: How to differentiate true and false benign?

[3] Weidong Chang, et al. Front Plant Sci. Diverged Early From CtpB and CtpC, CtpA Has Evolved to Process D1 Precursor in Oxygenic Photosynthetic Organisms

[4] Andrs Len-Torres, et al. Biol Res. CtpB is a plasma membrane copper (I) transporting P-type ATPase of Mycobacterium tuberculosis

[5] Markus Mastny, et al. Cell. CtpB assembles a gated protease tunnel regulating cell-cell signaling during spore formation in Bacillus subtilis

Related Histone Acetyltransferase Products
CPI-1612

CPI-1612 is a tool compound that appears to be a fairly efficient EP300/CBP histone acetyltransferase (HAT) inhibitor, exhibiting activity in xenograft models with good PK of higher species.

Butyrolactone 3

Butyrolactone 3 (MB-3) is a specifical small-molecule inhibitor of the histone acetyltransferase Gcn5 (IC50=100 μM), which has a high affinity to the Gcn5 enzyme comparable to that of its natural substrate, histone H3.

WM-3835

WM-3835 is a potent, highly specific HBO1 (KAT7 or MYST2) inhibitor that binds directly to the acetyl-Coenzyme A binding site of HBO1 33 and WM-3835 activates apoptosis while inhibiting proliferation, migration, and invasion of osteosarcoma (OS) cells. WM-3835 has anti-tumor activity and effectively inhibits the growth of osteosarcoma xenografts in mice.

WM-1119

WM-1119 is a highly potent, selective inhibitor of lysine acetyltransferase KAT6A with IC50 of 0.25 μM, Kd of 2 nM, WM-1119 is a reversible competitor of acetyl coenzyme A and inhibits MYST-catalysed histone acetylation.

TH1834

TH1834 is a specific Tip60 (KAT5) histone acetyltransferase (HAT) inhibitor.

  Catalog
Abmole Inhibitor Catalog




Keywords: CTPB supplier, Histone Acetyltransferase, inhibitors

Contact Us

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2020 AbMole BioScience. All Rights Reserved.