CTPB is a good activator of p300 histone acetyl transferase (HAT) enzyme.
|Solubility (25°C)||DMSO 62.5 mg/mL|
Powder -20°C 3 years ; 4°C 2 years
In solvent -80°C 6 months ; -20°C 1 month
|Body Surface Area (m2)||0.007||0.025||0.15||0.05||0.02||0.5|
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|
|Animal A Km|
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
 Oliver Shey-Njila, et al. Int J Mol Sci. CtpB Facilitates Mycobacterium tuberculosis Growth in Copper-Limited Niches
 Lei Li, et al. J Cancer Res Ther. Benign pathologies results from lung nodule percutaneous biopsies: How to differentiate true and false benign?
 Weidong Chang, et al. Front Plant Sci. Diverged Early From CtpB and CtpC, CtpA Has Evolved to Process D1 Precursor in Oxygenic Photosynthetic Organisms
 Andrs Len-Torres, et al. Biol Res. CtpB is a plasma membrane copper (I) transporting P-type ATPase of Mycobacterium tuberculosis
 Markus Mastny, et al. Cell. CtpB assembles a gated protease tunnel regulating cell-cell signaling during spore formation in Bacillus subtilis
|Related Histone Acetyltransferase Products|
TTK21 is an activator of the histone acetyltransferases CBP/p300. TTK21 can cross the blood-brain barrier, and reaches different parts of the brain when conjugated to glucose-based carbon nanosphere (CSP). TTK21 has potential for research of brain neurogenesis and long-term memory function.
CTB is a potent p300 histone acetyltransferase activator. CTB induces time dependence apoptosis of MCF-7 cells.
CPI-1612 is a tool compound that appears to be a fairly efficient EP300/CBP histone acetyltransferase (HAT) inhibitor, exhibiting activity in xenograft models with good PK of higher species.
Butyrolactone 3 (MB-3) is a specifical small-molecule inhibitor of the histone acetyltransferase Gcn5 (IC50=100 μM), which has a high affinity to the Gcn5 enzyme comparable to that of its natural substrate, histone H3.
WM-3835 is a potent, highly specific HBO1 (KAT7 or MYST2) inhibitor that binds directly to the acetyl-Coenzyme A binding site of HBO1 33 and WM-3835 activates apoptosis while inhibiting proliferation, migration, and invasion of osteosarcoma (OS) cells. WM-3835 has anti-tumor activity and effectively inhibits the growth of osteosarcoma xenografts in mice.
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