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TH1834

Cat. No. M9919
TH1834 Structure
Synonym:

TH-1834

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10mg USD 360  USD360 Out of stock
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Quality Control & Documentation
Biological Activity

TH1834 is a specific Tip60 (KAT5) histone acetyltransferase (HAT) inhibitor. TH1834 significantly inhibits Tip60 activity in vitro and treating cells with TH1834 results in apoptosis and increased unrepaired DNA damage in breast cancer.

Chemical Information
Molecular Weight 568.71
Formula C33H40N6O3
CAS Number 2108830-08-4
Solubility (25°C) DMSO 5 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Chunxia Gao, et al. Sci Rep. Rational design and validation of a Tip60 histone acetyltransferase inhibitor

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Keywords: TH1834, TH-1834 supplier, Histone Acetyltransferase, inhibitors, activators

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