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WM-1119

Cat. No. M10585

All AbMole products are for research use only, cannot be used for human consumption.

WM-1119 Structure
Synonym:

WM1119

Size Price Availability Quantity
5mg USD 55  USD55 In stock
10mg USD 75  USD75 In stock
25mg USD 140  USD140 In stock
50mg USD 240  USD240 In stock
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Quality Control & Documentation
Biological Activity

WM-1119 is a highly potent and selective KAT6A inhibitor, with an IC50 of 0.25 μM for KAT6A in lymphoma cells, the binding KD values of WM-1119 with KAT6A, KAT5 and KAT7 are 2 nM, 2.2 μM, 0.5 μM , respectively. WM-1119 induces cell cycle exit and cellular senescence without causing DNA damage. Treatment of MEFs with WM-1119 results in cell cycle arrest in G1 and a senescence phenotype. WM-1119 arrests the progression of lymphoma in mice. WM-1119 is well-tolerated; mice show no generalized ill effects and weight loss is not observed. The proportion and overall number of tumour cells is substantially reduced by WM-1119 treatment (four times per day).

Chemical Information
Molecular Weight 389.38
Formula C18H13F2N3O3S
CAS Number 2055397-28-7
Solubility (25°C) DMSO 80 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Jonathan B Baell, et al. Nature. Inhibitors of histone acetyltransferases KAT6A/B induce senescence and arrest tumour growth

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  Catalog
Abmole Inhibitor Catalog




Keywords: WM-1119, WM1119 supplier, Histone Acetyltransferase, inhibitors, activators

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