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WM-3835

Cat. No. M11175
WM-3835  Structure
Size Price Availability Quantity
5mg USD 90  USD90 In stock
10mg USD 150  USD150 In stock
25mg USD 320  USD320 In stock
50mg USD 480  USD480 In stock
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Quality Control & Documentation
Biological Activity

WM-3835 is a potent, highly specific HBO1 (KAT7 or MYST2) inhibitor that binds directly to the acetyl-Coenzyme A binding site of HBO1 33 and WM-3835 activates apoptosis while inhibiting proliferation, migration, and invasion of osteosarcoma (OS) cells. WM-3835 has anti-tumor activity and effectively inhibits the growth of osteosarcoma xenografts in mice.

Chemical Information
Molecular Weight 400.42
Formula C20H17FN2O4S
CAS Number 2229025-70-9
Solubility (25°C) DMSO ≥ 60 mg/mL
Storage 4°C, protect from light, dry, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Teng-Fei Chen, et al. Int J Biol Sci. HBO1 induces histone acetylation and is important for non-small cell lung cancer cell growth

[2] Jingtian Su, et al. Pharmacol Res. The role of MOZ/KAT6A in hematological malignancies and advances in MOZ/KAT6A inhibitors

[3] Yan-Yang Gao, et al. Theranostics. The histone acetyltransferase HBO1 functions as a novel oncogenic gene in osteosarcoma

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Keywords: WM-3835 supplier, Histone Acetyltransferase, inhibitors, activators


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