Free shipping on all orders over $ 500

Butyrolactone 3

Cat. No. M13827
Butyrolactone 3 Structure
Synonym:

MB-3

Size Price Availability
5mg USD 330  USD330 Out of stock
10mg USD 550  USD550 Out of stock
25mg USD 980  USD980 Out of stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control & Documentation
Biological Activity

Butyrolactone 3 (MB-3) is a specifical small-molecule inhibitor of the histone acetyltransferase Gcn5 (IC50=100 μM), which has a high affinity to the Gcn5 enzyme comparable to that of its natural substrate, histone H3. Butyrolactone 3 shows weak inhibitory on CBP (IC50=0.5 mM)

*The compound is unstable in solutions, freshly prepared is recommended



Chemical Information
Molecular Weight 184.19
CAS Number 778649-18-6
Solubility (25°C) DMSO 90 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Stefanie Beck, et al. ChemistryOpen. Protonation of γ-Butyrolactone and γ-Butyrolactam

[2] Stefanie Beck, et al. ChemistryOpen. Protonation of γ-Butyrolactone and γ-Butyrolactam

[3] Wang Ling-Yan, et al. J Mol Graph Model. Gamma-butyrolactone drug detection by Al-doped BC 3 nanotubes: A density functional theory study

[4] Xingyu Zhang, et al. J Org Chem. Sc(OTf) 3-Catalyzed Chemodivergent Annulations of γ-Butyrolactone-Fused Cyclopropanes with Anthranils

[5] Gang Chen, et al. Nat Prod Res. 3″-Hydroxymethyl-butyrolactone II from Aspergillus sp

Related Histone Acetyltransferase Products
TTK21

TTK21 is an activator of the histone acetyltransferases CBP/p300. TTK21 can cross the blood-brain barrier, and reaches different parts of the brain when conjugated to glucose-based carbon nanosphere (CSP). TTK21 has potential for research of brain neurogenesis and long-term memory function.

CTB

CTB is a potent p300 histone acetyltransferase activator. CTB induces time dependence apoptosis of MCF-7 cells.

CPI-1612

CPI-1612 is a tool compound that appears to be a fairly efficient EP300/CBP histone acetyltransferase (HAT) inhibitor, exhibiting activity in xenograft models with good PK of higher species.

CTPB

CTPB is a good activator of p300 histone acetyl transferase (HAT) enzyme.

WM-3835

WM-3835 is a potent, highly specific HBO1 (KAT7 or MYST2) inhibitor that binds directly to the acetyl-Coenzyme A binding site of HBO1 33 and WM-3835 activates apoptosis while inhibiting proliferation, migration, and invasion of osteosarcoma (OS) cells. WM-3835 has anti-tumor activity and effectively inhibits the growth of osteosarcoma xenografts in mice.

  Catalog
Abmole Inhibitor Catalog




Keywords: Butyrolactone 3, MB-3 supplier, Histone Acetyltransferase, inhibitors, activators

Contact Us

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2020 AbMole BioScience. All Rights Reserved.