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Butyrolactone 3

Cat. No. M13827
Butyrolactone 3 Structure
Synonym:

MB-3

Size Price Availability
5mg USD 330  USD330 Out of stock
10mg USD 550  USD550 Out of stock
25mg USD 980  USD980 Out of stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Butyrolactone 3 (MB-3) is a specifical small-molecule inhibitor of the histone acetyltransferase Gcn5 (IC50=100 μM), which has a high affinity to the Gcn5 enzyme comparable to that of its natural substrate, histone H3. Butyrolactone 3 shows weak inhibitory on CBP (IC50=0.5 mM)

*The compound is unstable in solutions, freshly prepared is recommended



Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 184.19
Formula
CAS Number 778649-18-6
Purity >99%
Solubility DMSO 90 mg/mL
Storage at -20°C
References

[1] Stefanie Beck, et al. ChemistryOpen. Protonation of γ-Butyrolactone and γ-Butyrolactam

[2] Stefanie Beck, et al. ChemistryOpen. Protonation of γ-Butyrolactone and γ-Butyrolactam

[3] Wang Ling-Yan, et al. J Mol Graph Model. Gamma-butyrolactone drug detection by Al-doped BC 3 nanotubes: A density functional theory study

[4] Xingyu Zhang, et al. J Org Chem. Sc(OTf) 3-Catalyzed Chemodivergent Annulations of γ-Butyrolactone-Fused Cyclopropanes with Anthranils

[5] Gang Chen, et al. Nat Prod Res. 3″-Hydroxymethyl-butyrolactone II from Aspergillus sp

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Keywords: Butyrolactone 3, MB-3 supplier, Histone Acetyltransferase, inhibitors

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