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Butyrolactone 3

Cat. No. M13827
Butyrolactone 3 Structure


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5mg USD 440  USD440 In stock
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Biological Activity

Butyrolactone 3 (MB-3) is a specifical small-molecule inhibitor of the histone acetyltransferase Gcn5 (IC50=100 μM), which has a high affinity to the Gcn5 enzyme comparable to that of its natural substrate, histone H3. Butyrolactone 3 shows weak inhibitory on CBP (IC50=0.5 mM)

*The compound is unstable in solutions, freshly prepared is recommended

Chemical Information
Molecular Weight 184.19
CAS Number 778649-18-6
Solubility (25°C) DMSO 90 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.


[1] Stefanie Beck, et al. ChemistryOpen. Protonation of γ-Butyrolactone and γ-Butyrolactam

[2] Stefanie Beck, et al. ChemistryOpen. Protonation of γ-Butyrolactone and γ-Butyrolactam

[3] Wang Ling-Yan, et al. J Mol Graph Model. Gamma-butyrolactone drug detection by Al-doped BC 3 nanotubes: A density functional theory study

[4] Xingyu Zhang, et al. J Org Chem. Sc(OTf) 3-Catalyzed Chemodivergent Annulations of γ-Butyrolactone-Fused Cyclopropanes with Anthranils

[5] Gang Chen, et al. Nat Prod Res. 3″-Hydroxymethyl-butyrolactone II from Aspergillus sp

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Keywords: Butyrolactone 3, MB-3 supplier, Histone Acetyltransferase, inhibitors, activators

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