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Butyrolactone 3 (MB-3) is a specifical small-molecule inhibitor of the histone acetyltransferase Gcn5 (IC50=100 μM), which has a high affinity to the Gcn5 enzyme comparable to that of its natural substrate, histone H3. Butyrolactone 3 shows weak inhibitory on CBP (IC50=0.5 mM)
*The compound is unstable in solutions, freshly prepared is recommended
| Molecular Weight | 184.19 |
| CAS Number | 778649-18-6 |
| Solubility (25°C) | DMSO 90 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[1] Stefanie Beck, et al. ChemistryOpen. Protonation of γ-Butyrolactone and γ-Butyrolactam
[2] Stefanie Beck, et al. ChemistryOpen. Protonation of γ-Butyrolactone and γ-Butyrolactam
[5] Gang Chen, et al. Nat Prod Res. 3″-Hydroxymethyl-butyrolactone II from Aspergillus sp
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KAT modulator-1 is a KAT modulator. |
| KAT6-IN-1
KAT6-IN-1 is a potent KAT6 inhibitor. |
| MC4171
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