|N-Nitroso-N-methylurea (NMU; MNU; NMH is an effective carcinogenic, mutagenic and teratogenic agent. N-nitroso-n-methylurea is a direct-acting alkylating agent that interacts with DNA. N-nitroso-n-methylurea targets a variety of animal organs to cause various cancers and/or degenerative diseases. N-nitroso-n-methylurea is also a precursor in diazomethane synthesis.
|4-Hydroperoxy cyclophosphamide, the active metabolite form of the precursor Cyclophosphamide, cross-links DNA and induces T-cell apoptosis independent of caspase receptor activation, as well as activating the mitochondrial death pathway through the generation of reactive oxygen species (ROS). It can be used in studies related to rheumatoid arthritis and autoimmune diseases.
|Semustine is a methylated derivative of Carmustine and also a DNA alkylating agent, which can form covalent bonds with nucleophilic centers in DNA, causing depurination, base pair miscoding, strand breaks, and DNA-DNA cross-linking, and has antitumor activity.
|Methyl methanesulfonate is a SN2-type alkylating agent that primarily methylates the nitrogen atom in purines and has apoptosis-inducing effects.
|Treosulfan (NSC 39069) is a bifunctional alkylating agent with activity in ovarian cancer and other solid tumor types.
|Bendamustine (SDX-105 free base), a purine analogue, is a DNA cross-linking agent. Bendamustine activates DNA-damage stress response and apoptosis. Bendamustine has potent alkylating, anticancer and antimetabolite properties.
|Palifosfamide(Isophosphoramide mustard; IPM; Zio-201) is a new DNA alkylation agent and active metabolite of isocyclophosphamide, which has anticancer activity.
|Miriplatin is a chemotherapy agent which belongs to the class of alkylating agents.
|The calicheamicins are a class of enediyne antitumor antibiotics derived from the bacterium Micromonospora echinospora, with calicheamicin γ1 being the most notable.
|Trioxsalen is a furanocoumarin and a psoralen derivative, in conjunction with UV-A for phototherapy treatment of vitiligo and hand eczema. After photoactivation it creates interstrand cross-links in DNA, which can cause programmed cell death.
|Thio-TEPA(Thioplex; Tiofosfamid) is an alkylating agent used to treat cancer, this molecule features tetrahedral phosphorus and is structurally akin to phosphate.
|Fotemustine (S 10036) is a nitrosourea alkylating agent approved for use in the treatment of metastasising melanoma.
|Busulfan is a cell cycle non-specific alkylating antineoplastic agent. Busulfan causes DNA damage by cross-linking DNAs and DNA and proteins. Busulfan also inhibits thioredoxin reductase.
|Lomustine inhibits cancer cells by damaging the DNA and stops cells from dividing.
|Carmustine is an alkylating antineoplastic agent for inhibiting the growth of U87MG glioblastoma cells with IC50 of 1.42 μM.
|Altretamine is an antitumor agent which also acts as a chemosterilant for male houseflies and other insects.
|Dacarbazine (DTIC-Dome; DTIC) is an alkylating agent that acts as a purine nucleotide precursor analog to inhibit purine nucleotide synthesis, thereby inhibiting DNA/RNA Synthesis, and can be used in studies related to melanoma and Hodgkin's lymphoma.
|Bendamustine hydrochloride is a DNA-alkylator with a distinct pattern of activity.
|Apaziquone is a bioreductive procompound and a chemical analog of the older chemotherapeutic agent mitomycin C.
|Diaziquone is a water-soluble synthetic aziridinyl benzoquinone that selectively alkylates and cross-links DNA, inhibits DNA replication, induces apoptosis, and inhibits the proliferation of tumor cells, with potential antitumor activity.
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