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Semustine is a methylated derivative of Carmustine and also a DNA alkylating agent, which can form covalent bonds with nucleophilic centers in DNA, causing depurination, base pair miscoding, strand breaks, and DNA-DNA cross-linking, and has antitumor activity.
| Molecular Weight | 247.72 |
| Formula | C10H18ClN3O2 |
| CAS Number | 13909-09-6 |
| Form | Solid |
| Solubility (25°C) | DMSO 100 mg/mL Ethanol 50 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[4] P E Kintzel. Drug Saf. Anticancer drug-induced kidney disorders
[5] R B Weiss et al. Cancer Treat Rep. Nephrotoxicity of semustine
| Related DNA Alkylator/Crosslinker Products |
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| Illudin S
Illudin S, a cytotoxic Illudin, is a natural sesquiterpene with strong anti-tumour and antiviral activities. |
| Illudin M
Illudin M is a cytotoxic fungal sesquiterpene that can be isolated from the culture medium of Omphalotus illudens mushrooms. |
| Sibiromycin
Sibiromycin is a naturally produced glycosylated pyrrolobenzodiazepines (PBDs). |
| Mitobronitol
Mitobronitol (Myelobromol; DBM) is a brominated analog of mannitol, also known as an anticancer agent that is classified as an alkylating agent. |
| Duocarmycin analog-2
Duocarmycin analog-2 is a potent DNA alkylating agent. |
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