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4-Hydroperoxy cyclophosphamide

Cat. No. M45348

All AbMole products are for research use only, cannot be used for human consumption.

4-Hydroperoxy cyclophosphamide Structure
Size Price Availability
1mg USD 227  USD227 3-4 Weeks
5mg USD 450  USD450 3-4 Weeks
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Biological Activity

4-Hydroperoxy cyclophosphamide, the active metabolite form of the precursor Cyclophosphamide, cross-links DNA and induces T-cell apoptosis independent of caspase receptor activation, as well as activating the mitochondrial death pathway through the generation of reactive oxygen species (ROS). It can be used in studies related to rheumatoid arthritis and autoimmune diseases.

Chemical Information
Molecular Weight 293.08
Formula C7H15Cl2N2O4P
CAS Number 39800-16-3
Form Solid
Solubility (25°C) DMSO 50 mg/mL
Storage -20°C
References

[1] Hong-Qing Niu, et al. Int Immunopharmacol. Combination of 4-hydroperoxy cyclophosphamide and methotrexate inhibits IL-6/sIL-6R-induced RANKL expression in fibroblast-like synoviocytes via suppression of the JAK2/STAT3 and p38MAPK signaling pathway

[2] G Strauss, et al. Cell Death Differ. 4-hydroperoxy-cyclophosphamide mediates caspase-independent T-cell apoptosis involving oxidative stress-induced nuclear relocation of mitochondrial apoptogenic factors AIF and EndoG

[3] R Fleer, et al. Chem Biol Interact. Toxicity, interstrand cross-links and DNA fragmentation induced by 'activated' cyclophosphamide in yeast: comparative studies on 4-hydroperoxy-cyclophosphamide, its monofunctional analogon, acrolein, phosphoramide mustard, and nor-nitrogen mustard

[4] G H Boerrigter, et al. Clin Exp Immunol. Local administration of cytostatic drug 4-hydroperoxy-cyclophosphamide (4-HPCY) facilitates cell-mediated immune reactions

[5] G H Boerrigter, et al. Immunopharmacology. Intradermal administration of 4-hydroperoxy-cyclophosphamide during contact sensitization potentiates effector T cell responsiveness in draining lymph nodes

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Keywords: 4-Hydroperoxy cyclophosphamide supplier, DNA Alkylator/Crosslinker, inhibitors, activators

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