Alkylator/Crosslinker
| Cat.No. | Name | Information |
|---|---|---|
| M11369 | N-Nitroso-N-methylurea | N-Nitroso-N-methylurea (NMU; MNU; NMH is an effective carcinogenic, mutagenic and teratogenic agent. N-nitroso-n-methylurea is a direct-acting alkylating agent that interacts with DNA. N-nitroso-n-methylurea targets a variety of animal organs to cause various cancers and/or degenerative diseases. N-nitroso-n-methylurea is also a precursor in diazomethane synthesis. |
| M3356 | Busulfan | Busulfan is a cell cycle non-specific alkylating antineoplastic agent. Busulfan causes DNA damage by cross-linking DNAs and DNA and proteins. Busulfan also inhibits thioredoxin reductase. |
| M2157 | Apaziquone | Apaziquone is a bioreductive procompound and a chemical analog of the older chemotherapeutic agent mitomycin C. |
| M55959 | Illudin M | Illudin M is a cytotoxic fungal sesquiterpene that can be isolated from the culture medium of Omphalotus illudens mushrooms. |
| M55958 | Sibiromycin | Sibiromycin is a naturally produced glycosylated pyrrolobenzodiazepines (PBDs). |
| M55957 | Mitobronitol | Mitobronitol (Myelobromol; DBM) is a brominated analog of mannitol, also known as an anticancer agent that is classified as an alkylating agent. |
| M55956 | Duocarmycin analog-2 | Duocarmycin analog-2 is a potent DNA alkylating agent. |
| M55955 | VH032 amide-PEG1-acid | VH032 amide-PEG1-acid (linker 10) is a VHL-1 alkyl linker that can be used to bind CDK4/6 ligands (PI) and degradation/destruction tags (EL) (e.g.,E3 ligase ligands). |
| M55954 | Phosphoramide mustard | Phosphoramide mustard is a biologically active metabolite of Cyclophosphamide, with anticancer activitiy. |
| M55953 | Phosphoramide mustard cyclohexanamine | Phosphoramide mustard cyclohexanamine is a biologically active metabolite of Cyclophosphamide, with anticancer activitiy. |
| M54806 | LP-284 | LP-284 is a potent DNA alkylating agent that kills solid tumours. LP-284 can be used in the studies of hematologic cancers with compromised DNA repair, such as mantle cell lymphoma (MCL). |
| M40729 | Diaziquone | Diaziquone is a water-soluble synthetic aziridinyl benzoquinone that selectively alkylates and cross-links DNA, inhibits DNA replication, induces apoptosis, and inhibits the proliferation of tumor cells, with potential antitumor activity. |
| M30947 | Mipicoledine | Mipicoledine is a potential neuro-alkylating agent for study of glioblastoma and metastatic cancers involving the central nervous system. |
| M30458 | Procarbazine | Procarbazine is an orally active alkylating agent, with anticancer activity. Procarbazine can be used in Hodgkin's disease research. |
| M30384 | PIP-199 | PIP-199 is a selective inhibitor of RMI (RecQ-mediated genome instability protein) core complex/MM2 interaction, with an IC50 of 36 μM. PIP-199 can be used for the research of sensitizing resistant tumors to DNA crosslinking chemotherapeutics. |
| M29513 | SJG-136 | SJG-136 is a DNA cross-linking agent, with an XL50 of 45 nM for pBR322 DNA. SJG-136 has potent antitumor activity. |
| M28642 | SG3199 | SG3199 is a cytotoxic DNA minor groove interstrand crosslinking pyrrolobenzodiazepine (PBD) dimer. SG3199 is the released warhead component of the ADC payload Tesirine (SG3249). |
| M28628 | (-)-Irofulven | (-)-Irofulven (MGI 114), an Illudin S analog, is a DNA alkylating agent. (-)-Irofulven inhibits the replication of DNA, induces tumor cells apoptosis, and has potent antitumor activity. |
| M28129 | Satraplatin | Satraplatin is an alkylating agent, with potent antitumor effect. |
| M10853 | Melflufen | Melflufen (Melphalan flufenamide), a dipeptide precursor of Melphalan, is an alkylator. Melflufen has antitumor activity against multiple myeloma cells and inhibits angiogenesis. Melflufen acts on irreversible damage and cytotoxicity of myeloma cell DNA. |
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