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Melflufen

Cat. No. M10853

All AbMole products are for research use only, cannot be used for human consumption.

Melflufen Structure

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Quality Control & Documentation
Biological Activity

Melflufen (Melphalan flufenamide), a dipeptide precursor of Melphalan, is an alkylator. Melflufen has antitumor activity against multiple myeloma cells and inhibits angiogenesis. Melflufen acts on irreversible damage and cytotoxicity of myeloma cell DNA.

Chemical Information
Molecular Weight 498.42
Formula C24H30Cl2FN3O3
CAS Number 380449-51-4
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Sohita Dhillon. Drugs. Melphalan Flufenamide (Melflufen): First Approval

[2] Paul G Richardson, et al. J Clin Oncol. Melflufen and Dexamethasone in Heavily Pretreated Relapsed and Refractory Multiple Myeloma

[3] Mara-Victoria Mateos, et al. J Clin Med. Melflufen: A Peptide-Drug Conjugate for the Treatment of Multiple Myeloma

[4] Albert Oriol, et al. Expert Opin Investig Drugs. Melflufen for relapsed and refractory multiple myeloma

[5] Paul G Richardson, et al. Lancet Haematol. Melflufen plus dexamethasone in relapsed and refractory multiple myeloma (O-12-M1): a multicentre, international, open-label, phase 1-2 study

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Keywords: Melflufen supplier, DNA Alkylator/Crosslinker, inhibitors, activators

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