All AbMole products are for research use only, cannot be used for human consumption.
Bendamustine hydrochloride (also known as SDX-105) is a DNA-damaging agent with IC50 of 50 μM. Bendamustine displays a distinct pattern of activity unrelated to other DNA-alkylating agents. Bendamustine hydrochloride activates a base excision DNA repair pathway rather than an alkyltransferase DNA repair mechanism. Bendamustine hydrochloride (SDX-105) inhibits mitotic checkpoints and induces mitotic catastrophe. The combination of bendamustine with fludarabine led to a highly synergistic effect in inducing apoptosis, which was 150% higher than expected for bendamustine plus fludarabine. Bendamustine has been used both as sole therapy and in combination with other agents including etoposide, fludarabine, mitoxantrone, methotrexate, prednisone, rituximab and vincristine.
| Molecular Weight | 394.72 |
| Formula | C16H21Cl2N3O2.HCl |
| CAS Number | 3543-75-7 |
| Form | Solid |
| Solubility (25°C) | DMSO 60 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related DNA Alkylator/Crosslinker Products |
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| Illudin M
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| Sibiromycin
Sibiromycin is a naturally produced glycosylated pyrrolobenzodiazepines (PBDs). |
| Mitobronitol
Mitobronitol (Myelobromol; DBM) is a brominated analog of mannitol, also known as an anticancer agent that is classified as an alkylating agent. |
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Duocarmycin analog-2 is a potent DNA alkylating agent. |
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