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Apaziquone

Cat. No. M2157

All AbMole products are for research use only, cannot be used for human consumption.

Apaziquone Structure
Synonym:

EO9

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10mg USD 650  USD650 Out of stock
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Quality Control & Documentation
Biological Activity

Apaziquone is a bioreductive prodrug and a chemical analog of the older chemotherapeutic agent mitomycin C with potential antineoplastic and radiosensitization activities. In hypoxic cells, apaziquone is converted to active metabolites by intracellular reductases. Intravesical administration of 4 mg/40 ml apaziquone was well tolerated and had ablative activity against superficial bladder cancer marker lesions.

Chemical Information
Molecular Weight 288.3
Formula C15H16N2O4
CAS Number 114560-48-4
Solubility (25°C) DMSO
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Phillips RM, et al. Br J Pharmacol. EO9 (Apaziquone): from the clinic to the laboratory and back again.

[2] Hendricksen K, et al. J Urol. Safety and side effects of immediate instillation of apaziquone following transurethral resection in patients with nonmuscle invasive bladder cancer.

[3] Puri R, et al. J Urol. Phase I/II pilot study of intravesical apaziquone (EO9) for superficial bladder cancer.

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Keywords: Apaziquone, EO9 supplier, DNA Alkylator/Crosslinker, inhibitors, activators

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