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Miriplatin

Cat. No. M8893

All AbMole products are for research use only, cannot be used for human consumption.

Miriplatin Structure
Synonym:

SM-11355

Size Price Availability Quantity
5mg USD 35  USD35 In stock
10mg USD 50  USD50 In stock
50mg USD 120  USD120 In stock
100mg USD 180  USD180 In stock
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Quality Control & Documentation
Biological Activity

Miriplatin is a DNA synthesis inhibitor.

In vitro: Miriplatin suspended in LPD (miriplatin/LPD, 100 μg/mL) inhibits the growth of AH109A cells, forms platinum-DNA adducts, and induces apoptosis.

In vivo: Miriplatin (0.02-0.4 mg/20 μL) in lipiodol reduces tumor growth rates in a dose dependent manner in rats bearing AH109A tumor cells. Miriplatin/LPD (400 μg/head) significantly reduces the growth of tumor in rats bearing AH109A cells.

Chemical Information
Molecular Weight 763.99
Formula C34H68N2O4Pt
CAS Number 141977-79-9
Form Solid
Solubility (25°C) chloroform 30 mg/mL (DMSO can inactivate Miriplatin's activity)
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Hanada M, et al. Cancer Chemother Pharmacol. Intra-hepatic arterial administration with miriplatin suspended in an oily lymphographic agent inhibits the growth of tumors implanted in rat livers by inducing platinum-DNA adducts to form and massive apoptosis.

[2] Kishimoto S, et al. Biol Pharm Bull. Antitumor effects of a novel lipophilic platinum complex (SM-11355) against a slowly-growing rat hepatic tumor after intra-hepatic arterial administration.

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Keywords: Miriplatin, SM-11355 supplier, DNA Alkylator/Crosslinker, inhibitors, activators

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