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Diaziquone

Cat. No. M40729

All AbMole products are for research use only, cannot be used for human consumption.

Diaziquone Structure
Synonym:

AZQ

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Quality Control & Documentation
Biological Activity

Diaziquone is a water-soluble synthetic aziridinyl benzoquinone that selectively alkylates and cross-links DNA, inhibits DNA replication, induces apoptosis, and inhibits the proliferation of tumor cells, with potential antitumor activity.

Chemical Information
Molecular Weight 364.35
Formula C16H20N4O6
CAS Number 57998-68-2
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] P E Kintzel. Drug Saf. Anticancer drug-induced kidney disorders

[2] S M Devine et al. Semin Oncol. New preparative regimens with diaziquone or cytarabine in combination with busulfan and cyclophosphamide

[3] J F Bender et al. Invest New Drugs. Diaziquone (AZQ)

[4] P L Gutierrez. Drug Metab Rev. The influence of ascorbic acid on the free-radical metabolism of xenobiotics: the example of diaziquone

[5] P L Gutierrez. Free Radic Biol Med. Mechanism(s) of bioreductive activation. The example of diaziquone (AZQ)

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Keywords: Diaziquone, AZQ supplier, DNA Alkylator/Crosslinker, inhibitors, activators

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