AChR/AChE Acetylcholine Receptors/Acetylcholinesterase

Cat.No.	Name	Information
M2489	Carbachol chloride	Carbachol is a cholinomimetic compound that binds and activates the acetylcholine receptor.
M3470	Oxybutynin	Oxybutynin is an anticholinergic medication used to relieve urinary and bladder difficulties.
M3190	PNU-282987	PNU-282987 is a highly selective α7 nAChR agonist with K_i of 27 nM.
M5683	Glycopyrrolate	Glycopyrrolate(Glycopyrronium Br) is a muscarinic competitive antagonist used as an antispasmodic.
M7227	EVP-6124 hydrochloride	EVP-6124 hydrochloride) is a novel partial agonist of α7 neuronal nicotinic acetylcholine receptors (nAChRs).
M8888	Donepezil	Donepezil(E 2020) is a specific and potent AChE inhibitor for bAChE and hAChE with IC50 of 8.12 nM and 11.6 nM, respectively.
M56255	AC-42	AC-42 is a poent M1 muscarinic selective allosteric agonist with EC50s of 805 nM and 220 nM for human wild-type and Y381A mutated M1 receptors, respectively.
M56254	ASP8302	ASP8302 is a positive allosteric modulator of muscarinic M3 Receptor.
M56253	VU6019650	VU6019650 is a potent and selective orthosteric antagonist of M5 mAChR (IC50=36 nM), can be used for opioid use disorder (OUD) relief.
M56252	LY 2033298	LY 2033298 is a selective positive allosteric modulator of the muscarinic M4 receptor.
M56251	mAChR-IN-1	mAChR-IN-1 is a potent muscarinic cholinergic receptor (mAChR) antagonist, with an IC50 of 17 nM.
M56250	Zamifenacin	Zamifenacin (UK-76654) is a potent gut-selective muscarinic M3 receptor antagonist.
M56249	Tolterodine	Tolterodine(PNU-200583) is a potent muscarinic receptor antagonists that show selectivity for the urinary bladder over salivary glands in vivo.
M56248	N-Demethyl MK-6884	N-Demethyl MK-6884 is a potent M4 mAChR allosteric modulator.
M56247	AC-42 hydrochloride	AC-42 hydrochloride is the hydrochloride salt form of AC-42.
M56246	Rapacuronium bromide	Rapacuronium bromide (Org 9487), a non-depolarizing neuromuscular blocker, is an allosteric modulator of muscarinic acetylcholine receptor (mAChR).
M56245	Zamifenacin fumarate	Zamifenacin fumarate (UK-76654 fumarate) is a potent gut-selective muscarinic M3 receptor antagonist.
M56244	mAChR-IN-1 hydrochloride	mAChR-IN-1 hydrochloride is a potent muscarinic cholinergic receptor (mAChR) antagonist, with an IC50 of 17 nM.
M54823	THRX-160209	THRX-160209 is a potent antagonist at the M(2) muscarinic acetylcholine (ACh) receptor subtype that was designed using a multivalent strategy, simultaneously targeting the orthosteric site and a nearby site known to bind allosteric ligands.
M54437	Catestatin	Catestatin is a 21-amino acid residue, cationic and hydrophobic peptide.
M54385	α-Conotoxin MII	α-Conotoxin MII (α-CTxMII), a 16-amino acid peptide from the venom of the marine snail Conus magus, potently blocks nicotinic acetylcholine receptors (nAChRs) composed of α3β2 subunits, with an IC50 of 0.5 nM.
M54173	COG 133 TFA	COG 133 TFA is a fragment of Apolipoprotein E (APOE) peptide.
M53102	G-Protein antagonist peptide	G-Protein antagonist peptide is the substance P-related peptide that inhibits binding of G proteins to their receptors.
M53101	α-Conotoxin M I	α-Conotoxin M I is a potent and selective inhibitor of mAChR and α1β1γδ nAChR, but has no effect on nicotine-stimulated dopamine release.
M52775	α-Conotoxin PnIA	α-Conotoxin PnIA, a potent and selective antagonist of the mammalian α7 nAChR, has the potential for the research of neurological conditions such as neuropathic pain and Alzheimer’s disease.
M52774	κ-Bungarotoxin	κ-Bungarotoxin (κ-Bgt) is a potent, selective, and slowly reversible antagonist of α3β2 neuronal nicotinic acetylcholine receptors with an IC50 of 2.30 nM.

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AChR/AChE Acetylcholine Receptors/Acetylcholinesterase

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