About 30 results found for searched term "Y 11" (0.01 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M1694 | CYC116 | Aurora Kinase |
| CYC116 is a potent, small molecule inhibitor of Aurora A, B and C with IC50 value of 44, 19 and 65 nM respectively. CYC-116 also inhibits VEGFR2, Src, Lck AND FLT3 with with Kis of 44, 82, 280, 44 nM, respectively. CYC-116 may have broad-spectrum antitumor activity. | ||
| M1700 | Momelotinib (CYT387) | JAK |
| LM-1149; Momelotinib; CYT 11387 | ||
| Momelotinib (CYT387) is a small-molecule, ATP-competitive JAK1/JAK2 inhibitor with IC50 of 11 and 18 nM respectively. | ||
| M1716 | Gemcitabine Hydrochloride | DNA/RNA Synthesis |
| Gemzar, LY-188011 | ||
| Gemcitabine (Gemzar, LY188011) inhibits DNA synthesis with an IC50 of 0.06 µM. | ||
| M1864 | SYN115 | Adenosine Receptor |
| Tozadenant | ||
| SYN115 is a novel, selective adenosine A(2A) receptor antagonist. | ||
| M1910 | Nepicastat hydrochloride | Dopamine Receptor |
| SYN117 | ||
| Nepicastat hydrochloride is a potent and selective inhibitor of both bovine and human dopamine-β-hydroxylase with IC50 of 8.5 nM and 9 nM, respectively. | ||
| M2040 | BAY 11-7082 | IκB/IKK |
| BAY 11-7821; NF-κB inhibitor 13 | ||
| BAY 11-7082 is an inhibitor of cytokine-induced IκB-α phosphorylation (IC50 ~ 10 μM). BAY 11-7082 inhibits ubiquitin-specific protease USP7 and USP21 (IC50=0.19, 0.96 μM, respectively). | ||
| M2130 | LY-411575 | Gamma-secretase/Beta-secretase |
| LSN-411575 | ||
| LY-411575 is potent and selective small molecule γ-secretase inhibitor with IC50 of 0.1 nM for APP23 and APP51/16 primary neurons. | ||
| M2172 | LY2811376 | Gamma-secretase/Beta-secretase |
| LY2811376 is an orally available, non-peptidic β-secretase inhibitor with IC50 of 239 nM-249 nM. | ||
| M2435 | Bay 11-7085 | IκB/IKK |
| Bay 11-7083 | ||
| BAY 11-7085 is an irreversible inhibitor of TNFα-induced IκBα phosphorylation with IC50 of 10 μM. | ||
| M2800 | KY02111 | Others |
| KY02111 is a widely used small molecule that boosts cardiomyogenesis. Chemical genetics of KY02111 identified squalene synthase (SQS) as a molecular target of KY02111. By disrupting the interaction of SQS with cardiac ER-membrane protein TMEM43, KY02111 impairs TGFβ/SMAD signaling and recapitulates the clinical mutation of TMEM43 that causes an inherited heart disease. | ||
| M2838 | Meptazinol hydrochloride | Opioid Receptor |
| IL-22811 hydrochloride; WY-22811 hydrochloride | ||
| Meptazinol is a unique centrally active opioid analgesic, which inhibits [3H]dihydromorphine binding with IC50 of 58 nM. | ||
| M3267 | Nepicastat | Others |
| SYN117, RS-25560-197 | ||
| Nepicastat is a dopamine beta-hydroxylase inhibitor with IC50 of 8.5 ±0.8 and 9.0 ±0.8 nM for bovine and human, respectively. | ||
| M3633 | Refametinib | MEK |
| BAY 86-9766, RDEA119 | ||
| Refametinib (BAY 86-9766, RDEA119) is a potent, highly selective and ATP non-competitive inhibitor of MEK1 and MEK2 with IC50 of 19 nM and 47 nM, respectively. | ||
| M3547 | Glibenclamide | Others |
| Glyburide; RP-1127; BIIB093 | ||
| Glibenclamide (Glyburide) is an orally active ATP-sensitive K+ channel (KATP) inhibitor. Glibenclamide inhibits P-glycoprotein. Glibenclamide directly binds and blocks the SUR1 subunits of KATP and inhibits the cystic fibrosis transmembrane conductance regulator protein (CFTR). | ||
| M3886 | WAY-262611 | Wnt/beta-catenin |
| WAY-262611 is a Wnt pathway agonist acting via inhibition of Dkk1 with no GSK-3β inhibition and the TCF-Luciferase EC50=0.63µM. | ||
| M1629 | Ramucirumab | VEGFR/PDGFR |
| LY3009806; IMC-1121B | ||
| Ramucirumab is a direct VEGFR2 antagonist, that binds with high affinity to the extracellular domain of VEGFR2 and block the binding of natural VEGFR ligands (VEGF-A, VEGF-C and VEGF-D). | ||
| M4319 | 23S-hydroxyl-11,15-dioxo-ganoderic-acid-DM | Others |
| 23S-hydroxyl-11,15-dioxo-ganoderic-acid-DM | ||
| M4852 | LY303511 | mTOR |
| LY303511 is a structural analogue of LY294002, which does not inhibit PI3K, increased homotypic GJIC. | ||
| M11228 | BAY1125976 | Akt |
| BAY1125976 is an Akt1/Akt2 selective allosteric inhibitor. The IC50 values of Akt1 and Akt2 inhibition at 10 μM ATP were 5.2 nM and 18 nM, respectively. | ||
| M5134 | WAY-181187 | 5-HT Receptor |
| SAX-187 | ||
| Way-181187 (SAX-187) is an effective selective 5-HT6 receptor agonist with Ki of 2.2 nM and EC50 of 6.6 nM. WAY181187 mediates 5-HT6 receptor-dependent signaling pathways, such as cAMP, Fyn and ERK1/2 kinases, as specific agonists. | ||
| M5285 | Ilaprazole | Proton Pump |
| IY-81149 | ||
| Ilaprazole, a substituted benzimidazole, is a new candidate drug that is an H+ /K+ ATPase inhibitor designed for the treatment of gastric ulcers. | ||
| M5533 | Corticosterone | GCR |
| 17-Deoxycortisol; 11β,21-Dihydroxyprogesterone; Kendall's compound B | ||
| Corticosterone (17-Deoxycortisol) is an orally active and adrenal cortex-produced glucocorticoid, which plays an important role in regulating neuronal functions of the limbic system. Corticosterone increases the Rab-mediated AMPAR membrane traffic via SGK-induced phosphorylation of GDI. | ||
| M5534 | Cortisone | GCR |
| 17-Hydroxy-11-dehydrocorticosterone; Kendall's compound E | ||
| Cortisone is a 21-carbon steroid hormone. Cortisone is one of the main hormones released by the adrenal gland in response to stress. | ||
| M5656 | Fluoxetine hydrochloride | 5-HT Receptor |
| LY-110140 | ||
| Fluoxetine hydrochloride is an antidepressant of the selective serotonin reuptake inhibitor (SSRI) class. | ||
| M5680 | Gemcitabine | DNA/RNA Synthesis |
| NSC 613327; LY188011 | ||
| Gemcitabine (LY-188011; NSC 613327) is a DNA synthesis inhibitor with IC50 of 50 nM, 40 nM, 18 nM and 12 nM in PANC1, MIAPaCa2, BxPC3 and Capan2 cells, respectively. Gemcitabine inhibits DNA synthesis and repair, resulting in autophagyand apoptosis. | ||
| M5916 | Radotinib | Src-bcr-Abl |
| IY-5511 | ||
| Radotinib is a selective BCR-ABL1 tyrosine kinase inhibitor with IC50 of 34 nM, used to treat Chronic Myeloid Leukemia. | ||
| M5952 | Saxagliptin hydrate | Dipeptidyl Peptidase |
| BMS-477118 hydrate, Onglyza hydrate, BMS 477118 hydrate, BMS477118 hydrate | ||
| Saxagliptin H2O is a selective and reversible DPP4 inhibitor with IC50 of 26 nM. | ||
| M6289 | Erythromycin cyclocarbonate | Antibiotic |
| Erythromycin cyclic carbonate; Erythromycin A 11,12-carbonate | ||
| Erythromycin Cyclocarbonate, derivative of Erythromycin, inhibits protein synthesis of bacteria by binding to the 50S ribosome. | ||
| M6389 | 1-Aminobenzotriazole (ABT) | Cytochrome P450 (e.g. CYP17) |
| ABT; 3-Aminobenzotriazole; 1-Benzotriazolylamine; NSC 114498; NSC 656987 | ||
| 1-Aminobenzotriazole (ABT) is a cytochrome P450 inhibitor; inhibits 20-HETE synthesis. | ||
| M7482 | WAY 181187 oxalate | Others |
| WAY 181187 oxalate is a high affinity and selective 5-HT 6 agonist. | ||
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