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Nepicastat is a dopamine beta-hydroxylase inhibitor with IC50 of 8.5 ±0.8 and 9.0 ±0.8 nM for bovine and human, respectively. Dopamine beta-hydroxylase is an enzyme that catalyzes the conversion of dopamine to norepinephrine. It has been studied as a possible treatment for congestive heart failure, and appears to be well tolerated as such.
| Cell Experiment | |
|---|---|
| Cell lines | |
| Preparation method | |
| Concentrations | |
| Incubation time | |
| Animal Experiment | |
|---|---|
| Animal models | Spontaneously hypertensive rats (SHRs). |
| Formulation | Nepicastat hydrochloride is dissolved in distilled water. |
| Dosages | ≤100 mg/kg |
| Administration | Administered via p.o. |
| Molecular Weight | 295.35 |
| Formula | C14H15F2N3S |
| CAS Number | 173997-05-2 |
| Solubility (25°C) | DMSO |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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