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Saxagliptin hydrate

Cat. No. M5952
Saxagliptin hydrate Structure
Synonym:

BMS-477118 hydrate, Onglyza hydrate, BMS 477118 hydrate, BMS477118 hydrate

Size Price Availability
10mg USD 120  USD120 4-7 Days
25mg USD 180  USD180 4-7 Days
50mg USD 270  USD270 4-7 Days
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Quality Control & Documentation
Biological Activity

Saxagliptin H2O is a selective and reversible DPP4 inhibitor with IC50 of 26 nM.

Chemical Information
Molecular Weight 333.43
Formula C18H25N3O2.H2O
CAS Number 945667-22-1
Solubility (25°C) 60 mg/mL in DMSO
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Schernthaner G, et al. Diabetes Obes Metab. Efficacy and tolerability of saxagliptin compared with glimepiride in elderly patients with type 2 diabetes: a randomized, controlled study (GENERATION).

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  Catalog
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Keywords: Saxagliptin hydrate, BMS-477118 hydrate, Onglyza hydrate, BMS 477118 hydrate, BMS477118 hydrate supplier, DPP-4, inhibitors, activators

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