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Saxagliptin hydrate

Cat. No. M5952
Saxagliptin hydrate Structure
Synonym:

BMS-477118 hydrate, Onglyza hydrate, BMS 477118 hydrate, BMS477118 hydrate

Size Price Availability
10mg USD 120  USD120 4-7 Days
25mg USD 180  USD180 4-7 Days
50mg USD 270  USD270 4-7 Days
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Saxagliptin H2O is a selective and reversible DPP4 inhibitor with IC50 of 26 nM.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 333.43
Formula C18H25N3O2.H2O
CAS Number 945667-22-1
Purity >98%
Solubility 60 mg/mL in DMSO
Storage at -20°C
References

[1] Schernthaner G, et al. Diabetes Obes Metab. Efficacy and tolerability of saxagliptin compared with glimepiride in elderly patients with type 2 diabetes: a randomized, controlled study (GENERATION).

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  Catalog
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Keywords: Saxagliptin hydrate, BMS-477118 hydrate, Onglyza hydrate, BMS 477118 hydrate, BMS477118 hydrate supplier, DPP-4, inhibitors

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