About 32 results found for searched term "Ten01" (0.075 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M28217 | (S)-JQ-35 | Epigenetic Reader Domain |
| TEN-010 | ||
| (S)-JQ-35 (TEN-010) is an inhibitor of the Bromodomain and Extra-Terminal (BET) family bromodomain-containing proteins with potential antineoplastic activity. | ||
| M49623 | Ten01 | JAK |
| Ten01 has 5.0 nM activity against JAK1 kinase. | ||
| M1736 | CH5132799 | PI3K |
| Izorlisib | ||
| CH5132799 is a novel and potent class I PI3K inhibitor with IC50 value of 0.014 μM. | ||
| M2000 | GW788388 | TGF-β Receptor |
| GW788388 is a potent selective inhibitor of TGF-beta type I receptor and ALK5 with IC50 values of 0.093 and 0.018 μM. | ||
| M2008 | ICG-001 | Wnt/beta-catenin |
| PRI-724 isomer | ||
| ICG-001 is a novel small molecule inhibitor of TCF/beta-catenin-mediated transcription. ICG-001 specifically binds to cyclic AMP response element-binding protein with an IC50 of 3 μM. | ||
| M2101 | PCI-34051 | HDAC |
| PCI-34051 is a potent histone deacetylase (HDAC) 8 inhibitor with IC50 of 0.01 μM. | ||
| M2204 | T0901317 | Liver X Receptor |
| T0901317 is a potent and selective agonist for both LXRα and LXRβ with an EC50 of 20~50 nM. T0901317 activates FXR with an EC50 of 5 μM. T0901317 is RORα and RORγ dual inverse agonist with Ki values of 132 nM and 51 nM, respectively. | ||
| M3216 | ARRY-520 | Kinesin |
| Filanesib | ||
| ARRY-520 is a potent and selective kinesin spindle protein (KSP) inhibitor with an IC50 of 15 nM for A2780, CP70 and 01-28 cell lines in vitro. | ||
| M3374 | Zolmitriptan | 5-HT Receptor |
| BW-311C90; 311C90 | ||
| Zolmitriptan is a 5-HT1B/1D-angiotensin receptor (5-HT1B/1D-AR) partial agonist with Ki's of 5.01 nM, 0.63 nM, and 63.09 nM for 5-HT1B, 5-HT1D, and 5-HT1F receptors, respectively.Zolmitriptan can be used in studies related to migraine. | ||
| M3700 | PF8380 | PDE |
| Pf-8380 is a potent autotaxin inhibitor with IC50 of 2.8 nM and 101 nM in in vitro enzyme assay and human whole blood cell assay, respectively. | ||
| M3767 | Merestinib | c-Met |
| LY2801653 | ||
| Merestinib (LY2801653) is a potent, orally bioavailable c-Met inhibitor (Ki=2 nM) with anti-tumor activities. Merestinib (LY2801653) also has potent activity against MST1R (IC50=11 nM), FLT3 (IC50=7 nM), AXL (IC50=2 nM), MERTK (IC50=10 nM), TEK (IC50=63 nM), ROS1, DDR1/2 (IC50=0.1/7 nM) and MKNK1/2 (IC50=7 nM). | ||
| M3802 | GF 109203X | PKC |
| GO 6850; Bisindolylmaleimide I | ||
| GF 109203X is a very potent and selective inhibitor of protein kinase C, selective for the α and β1 isoforms (IC50 values are 0.0084, 0.0180, 0.210, 0.132, and 5.8 μM for α, β1, δ, ε and ζ isoforms respectively). | ||
| M3929 | PF-06447475 | LRRK2 |
| PF-06447475 is a highly potent, selective, brain penetrant LRRK2 inhibitor with IC0 of 3 nM/11 nM for Wt LRRK2/G2019S LRRK2 respectively. | ||
| M3973 | Tazarotene | RAR/RXR |
| Tazorac; Zorac; AGN 190168 | ||
| Tazarotene (AGN 190168) is a new member of the acetylenic class of RARβ/γ selective retinoids which is approved to treat a variety of skin diseases, exhibits an anti-proliferative effect in human basal cell carcinoma (BCC) by triggering caspase-dependent apoptosis. | ||
| M4402 | Epiberberine | AChR/AChE |
| Epiberberine is a potent AChE and BChE inhibitor, and a non-competitive BACE1 inhibitor, with IC50s of 1.07, 6.03 and 8.55 μM, respectively. Epiberberine is also a potent inhibitor against both ureases with IC50 values of 3.0±0.01μM for HPU (ureases from Helicobacter pylori) and 2.3±0.01μM for JBU (ureases from jack bean). | ||
| M4831 | GSK2578215A | LRRK2 |
| GSK2578215A is a potent and selective LRRK2 kinase inhibitor with IC50 of 8.9 nM and 10.9 nM for LRRK2 (G2019S) and LRRK2 (WT), respectively. | ||
| M4913 | PFK-015 | PFKFB3 |
| PFK15 | ||
| PFK-015 is a potent and selective 6-phosphofructo-2-kinase (PFKFB3) inhibitor. PFK-015 inhibits recombinant PFKFB3 with an IC50 value of 110 nM and inhibits PFKFB3 activity in cancer cells with an IC50 value of 20 nM. | ||
| M4949 | LRRK2-IN-1 | LRRK2 |
| LRRK2-IN-1 is a potent and selective LRRK2 inhibitor with IC50 of 6 nM and 13 nM for LRRK2 (G2019S) and LRRK2 (WT), respectively. | ||
| M6186 | Repotrectinib (TPX-0005) | ALK |
| TPX-0005; Repotrectinib | ||
| Repotrectinib (TPX-0005) is a potential best-in-class ALK/ROS1/TRK inhibitor against SRC, wild-type WT ALK, The IC50 values of ALK G1202R and ALK L1196M were 5.3 nM, 1.01 nM, 1.26 nM and 1.08 nM, respectively. | ||
| M6649 | CZC-25146 | LRRK2 |
| CZC25146 | ||
| CZC 25146 is a potent and orally active LRRK2 inhibitor with IC50 values of 4.76 nM and 6.87 nM for wild-type LRRK2 and G2019S LRRK2, respectively. CZC-25146 inhibits PLK4, GAK, TNK1, CAMKK2 and PIP4K2C as well. | ||
| M7128 | PG 01 | CFTR |
| PG 01 is a potent CFTR Cl- channel potentiator.PG01 was effective against E193K, G970R and G551D (CFTR mutants) with Kd values of 0.22 μM, 0.45 μM and 1.94 μM, respectively.PG01 was also effective against ΔF508 (Ka 0.3 μM).PG01 increased ΔF508-CFTR Cl- currents with the addition of Forskolin. F508-CFTR Cl- current after the addition of Forskolin. | ||
| M7816 | GSK1016790A | TRP Channel |
| GSK 1016790A | ||
| GSK1016790A is a novel and potent transient receptor potential vanilloid 4 (TRPV4) channel agonist. GSK1016790A can elicit Ca2+ influx and elevate intracellular Ca2+ in HEK cells. | ||
| M8898 | APY0201 | PI3K |
| APY0201 is a potent and selective IL-12/23 inhibitor. APY0201 is also a potent PIKfyve inhibitor, which inhibits the conversion of PtdIns3P to PtdIns(3,5)P2 in the presence of in the presence of [33P]ATP with an IC50 of 5.2 nM. | ||
| M9152 | CPI-637 | Epigenetic Reader Domain |
| CPI-637 is a potent and selective CBP/EP300 bromodomains inhibitor with IC50 of 0.03±0.01μM and 11.0±0.6 μM for CBP/EP300 and BRD4, respectively. | ||
| M9246 | HUHS015 | Others |
| HUHS015 is a potent PCA-1/ALKBH3 inhibitor, which continuously administering HUHS015 significantly suppressed the growth of DU145 cells. | ||
| M10130 | AZD0156 | ATM/ATR |
| AZD-0156 | ||
| AZD0156 is a potent, selective and orally active ATM inhibitor with an IC50 of 0.58 nM. AZD0156 inhibits ATM mediated signal transduction, prevents DNA damage checkpoint activation, damages DNA damage repair, and induces tumor cell apoptosis. | ||
| M10704 | SM-276001 | TLR |
| SM-276001 is a potent and selective TLR7 agonist that induces an antitumor immune response. SM-276001 is an orally active interferon (IFN) inducer. | ||
| M10727 | Pulrodemstat benzenesulfonate | Histone demethylase |
| CC-90011 benzenesulfonate | ||
| CC-90011 (Pulrodemstat) benzenesulfonate is a potent, selective, reversible and orally active lysine-specific demethylase-1 (LSD1) inhibitor,IC50 0.25 nM. CC-90011 benzenesulfonate has less enzymatic inhibition of LSD2, MOA-A and MAO-B. CC-90011 benzenesulfonate induces differentiation of acute myeloid leukemia (AML) and small cell lung cancer (SCLC) cells and has potent anti-cancer activity. | ||
| M10761 | DC260126 | Apoptosis |
| DC260126 is a potent GPR40 (FFAR1) antagonist. DC260126 dose-dependent inhibits GPR40-mediated Ca of linoleic acid, oleic acid, palm oleic acid, and lauric acid irritation2+ ELEVATED (IC50 6.28, 5.96, 7.07, 4.58 μM, respectively). DC260126 is protective of palmitate-induced endoplasmic reticulum stress and apoptosis ( apoptosis ) . | ||
| M11040 | AMXT-1501 tetrahydrochloride | Apoptosis |
| AMXT-1501 tetrahydrochloride is an orally active polyamine transport inhibitor. AMXT-1501 blocks tumor growth in immunocompetent mice, but not T cell-deficient thymic nude mice. DFMO and AMXT-1501 jointly induce caspase-3-mediated apoptosis of NB cells. | ||
| M11263 | HJC0197 | Ras |
| HJC0197 is a potent antagonist of Epac1 (the exchange protein directly activated by cAMP 1) and Epac2 (IC50=5.9 μM for Epac2). HJC0197 selectively blocked camp-induced Epac activation. HJC0197 inhibited epAC1-mediated RAP1-GDP exchange activity in the presence of isoconcentration of cAMP. | ||
| M11527 | BCH001 | DNA/RNA Synthesis |
| 3-Quinolinecarboxylic acid | ||
| BCH001 is a quinoline derivative and a selective PAPD5 inhibitor. BCH001 restores telomerase activity and telomere length in pluripotent stem cells induced by congenital keratosis (DC). BCH001 did not inhibit poly (A) -specific ribonucase (PARN) or several other polynucleotide polymerases. PAPD5 is A nonnormalized Poly (A) polymerase with an unconventional RNA binding motif. | ||
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