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AZD0156

Cat. No. M10130
AZD0156 Structure
Synonym:

AZD-0156

Size Price Availability Quantity
10mg USD 135  USD135 In stock
50mg USD 397  USD397 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

AZD0156 is an orally bioavailable ataxia telangiectasia mutated (ATM) kinase inhibitor, with potential chemo-/radio-sensitizing and antineoplastic activities. AZD0156 binds to ATM, thereby inhibiting the kinase activity of ATM and ATM-mediated signaling. This prevents DNA damage checkpoint activation, disrupts DNA damage repair, induces tumor cell apoptosis, and leads to cell death of ATM-overexpressing tumor cells.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 461.56
Formula C26H31N5O3
CAS Number 1821428-35-6
Purity >99%
Solubility DMSO 2 mg/mL (Need warmed and ultrasonic)
Storage at -20°C
References

[1] Kurt G. Pike. AACR. Identifying high quality, potent and selective inhibitors of ATM kinase: Discovery of AZD0156

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: AZD0156, AZD-0156 supplier, ATM/ATR, inhibitors

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