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Pulrodemstat benzenesulfonate

Cat. No. M10727
Pulrodemstat benzenesulfonate Structure
Synonym:

CC-90011 benzenesulfonate

Size Price Availability Quantity
5mg USD 130  USD130 In stock
10mg USD 210  USD210 In stock
25mg USD 370  USD370 In stock
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Quality Control
Biological Activity

CC-90011 benzenesulfonate is a potent, selective, reversible and orally active lysine-specific demethylase-1 (LSD1) inhibitor,IC50 0.25 nM. CC-90011 benzenesulfonate has less enzymatic inhibition of LSD2, MOA-A and MAO-B. CC-90011 benzenesulfonate induces differentiation of acute myeloid leukemia (AML) and small cell lung cancer (SCLC) cells and has potent anti-cancer activity.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 609.65
Formula C30H29F2N5O5S
CAS Number 2097523-60-7
Purity >99%
Solubility DMSO ≥ 60 mg/mL
Storage -20°C, dry, sealed
References

[1] Toufike Kanouni, et al. J Med Chem. Discovery of CC-90011: A Potent and Selective Reversible Inhibitor of Lysine Specific Demethylase 1 (LSD1)

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Keywords: Pulrodemstat benzenesulfonate, CC-90011 benzenesulfonate supplier, Histone demethylases, inhibitors

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