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GSK-J1

Cat. No. M2730

All AbMole products are for research use only, cannot be used for human consumption.

GSK-J1 Structure
Size Price Availability Quantity
10mM*1mL in DMSO USD 65  USD65 In stock
5mg USD 40  USD40 In stock
10mg USD 63  USD63 In stock
25mg USD 98  USD98 In stock
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Quality Control & Documentation
Biological Activity

GSK-J1 is a potent inhibitor of H3K27me3/me2-demethylases JMJD3/KDM6B and UTX/KDM6A, with IC50 of 60 nM towards KDM6B. GSK J1 is selective for the H3K27 demethylases JMJD3 and UTX.

Chemical Information
Molecular Weight 389.45
Formula C22H23N5O2
CAS Number 1373422-53-7
Solubility (25°C) DMSO 40 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Wei Zhang, et al. Therapeutically targeting head and neck squamous cell carcinoma through synergistic inhibition of LSD1 and JMJD3 by TCP and GSK-J1

[2] Eric Murillo-Rodrguez, et al. Sleep and Neurochemical Modulation by DZNep and GSK-J1: Potential Link With Histone Methylation Status

[3] Sarder Arifuzzaman, et al. Research update and opportunity of non-hormonal male contraception: Histone demethylase KDM5B-based targeting

[4] Reza Raeisossadati, et al. Small Molecule GSK-J1 Affects Differentiation of Specific Neuronal Subtypes in Developing Rat Retina

[5] Bo Heinemann, et al. Inhibition of demethylases by GSK-J1/J4

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Keywords: GSK-J1 supplier, Histone demethylase, inhibitors, activators

All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.


 
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