| Cat.No. | Name | Information |
|---|---|---|
| M5149 | GSK-J4 | GSK-J4 is a cell permeable procompound rapidly hydrolyzed by macrophage esterases to GSK-J1, a potent selective jumonji H3K27 demethylase inhibitor. |
| M28644 | KDM5-C70 | KDM5-C70 is an ethyl ester derivative of KDM5-C49 and a potent, cell-permeable and pan-KDM5 histone demethylase inhibitor. KDM5-C70 has an antiproliferative effect in myeloma cells, leading to genome-wide elevation of H3K4me3 levels. |
| M15089 | PBIT | PBIT is a JARID1 (Jumonji AT-Rich Interactive Domain 1) inhibitor with IC50 values of 3, 4.9 and 6 μM for JARID1B, 1A and 1C, respectively. It can increase trimethylation of H3K4 in HeLa cells and block the proliferation of tumor cells expressing high levels of JARID1B. |
| M13838 | Seclidemstat mesylate | Seclidemstat (SP-2577) mesylate is a potent noncompetitive and reversible KDM1A (LSD1) inhibitor (Ki=31 nM, IC50=13 nM). |
| M13832 | GSK467 | GSK467 is a cell penetrant and selective KDM5B (JARID1B or PLU1) inhibitor with a Ki of 10 nM, shows 180-fold selectivity for KDM4C and no measurable inhibitory effects toward KDM6 or other Jumonji family members. |
| M10921 | GSK2879552 dihydrochloride | GSK2879552 dihydrochloride is an oral, irreversible LSD1/KDM1A inhibitor with antitumor activity. |
| M10727 | Pulrodemstat benzenesulfonate | CC-90011 (Pulrodemstat) benzenesulfonate is a potent, selective, reversible and orally active lysine-specific demethylase-1 (LSD1) inhibitor,IC50 0.25 nM. CC-90011 benzenesulfonate has less enzymatic inhibition of LSD2, MOA-A and MAO-B. CC-90011 benzenesulfonate induces differentiation of acute myeloid leukemia (AML) and small cell lung cancer (SCLC) cells and has potent anti-cancer activity. |
| M10726 | ORY-1001 (trans) | Dihydrochloride, Iadademstat (ORY-1001) is an irreversible inhibitor of selective Lysine-specific demethylase 1A (KDM1A/LSD1). |
| M9689 | Seclidemstat | Seclidemstat is an orally active, reversible, noncompetitive inhibitor of lysine-specific demethylase 1 (LSD1, or KDM1A) with a mean IC50 of 127 nM, it has potential antineoplastic activity. |
| M9644 | T-3775440 hydrochloride | T-3775440 hydrochloride is a potent, selecitve, irreversible LSD1 inhibitor with IC50 value of 2.1 nM. |
| M9526 | GSK-J5 | GSK-J5 is a cell-permeable, inactive control for histone demethylase JMJD3/UTX inhibitor GSK-J4. |
| M9375 | QC6352 | QC6352 is a potent KDM4C inhibitor. |
| M8937 | CPI-455 | CPI-455 is a potent and selective inhibitor of KDM5 demethylases which reduces survival of cancer cells, with a half-maximal inhibitory concentration (IC50) of 10 ± 1 nM for full-length KDM5A in enzymatic assays. |
| M8409 | ML324 | ML324 is a potent JMJD2 demethylase inhibitor that is highly effective in reducing herpes simplex virus (HSV) IE gene expression. |
| M6831 | IOX1 | IOX1 is a histone demethylase inhibitor; cell permeable. IOX1 also inhibits ALKBH5. |
| M6650 | Daminozide | DaminoDaminozide is a plant growth regulator and selective inhibitor of human KDM2/7 histone demethylases, with IC50 values of 0.55, 1.5, and 2.1 μM for PHF8, KDM2A, and KIAA1718, respectively.Daminozide is >100-fold selective for KDM2/7 demethylases compared to other demethylase subfamily members tested. zide is a selective KDM2/7 inhibitor. |
| M6259 | CP2 | CP2 is a cyclic peptide that inhibits the JmjC histone demethylases KDM4 with IC50 values of 42 nM and 29 nM for KDM4A and KDM4C, respectively. |
| M6143 | SP2509 | SP2509 is A selective histone demethylase LSD1 inhibitor. SP2509 is also effective. It is A selective LSD1 antagonist with an IC50 of 13 nM and has no activity against MAO-A, MAO-B, lactate dehydrogenase and glucose oxidase. |
| M5762 | Mebhydrolin napadisylate | Mebhydrolin (napadisylate) is an antihistamine, used for symptomatic relief of allergic symptoms caused by histamine release, including nasal allergies and allergic dermatosis. |
| M5213 | ORY-1001 (Iadademstat) | ORY-1001 (RG-6016) is the only dual KDM1A/LSD1 inhibitor, and it is also the only KDM1A inhibitor in development for the treatment of neurodegenerative disease. |
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