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Histone demethylases Histone demethylases


Cat.No.  Name Information
M5149 GSK-J4 GSK-J4 is a cell permeable procompound rapidly hydrolyzed by macrophage esterases to GSK-J1, a potent selective jumonji H3K27 demethylase inhibitor.
M10826 GSK 690 Hydrochloride GSK 690 (Hydrochloride) is a reversible inhibitor of lysine-specific demethylase 1 (LSD1),Kd The value is 9 nM,IC50 The value is 37 nM.
M10727 Pulrodemstat benzenesulfonate CC-90011 benzenesulfonate is a potent, selective, reversible and orally active lysine-specific demethylase-1 (LSD1) inhibitor,IC50 0.25 nM. CC-90011 benzenesulfonate has less enzymatic inhibition of LSD2, MOA-A and MAO-B. CC-90011 benzenesulfonate induces differentiation of acute myeloid leukemia (AML) and small cell lung cancer (SCLC) cells and has potent anti-cancer activity.
M9689 Seclidemstat Seclidemstat is an orally active, reversible, noncompetitive inhibitor of lysine-specific demethylase 1 (LSD1, or KDM1A) with a mean IC50 of 127 nM, it has potential antineoplastic activity.
M9644 T-3775440 hydrochloride T-3775440 hydrochloride is a potent, selecitve, irreversible LSD1 inhibitor with IC50 value of 2.1 nM.
M9526 GSK-J5 GSK-J5 is a cell-permeable, inactive control for histone demethylase JMJD3/UTX inhibitor GSK-J4.
M9375 QC6352 QC6352 is a potent KDM4C inhibitor.
M8937 CPI-455 HCl CPI-455 HCl is a potent and selective inhibitor of KDM5 demethylases which reduces survival of drug-tolerant cancer cells, with a half-maximal inhibitory concentration (IC50) of 10 ± 1 nM for full-length KDM5A in enzymatic assays.
M6831 IOX1 IOX1 is a histone demethylase inhibitor; cell permeable. IOX1 also inhibits ALKBH5.
M6650 Daminozide Daminozide is a selective KDM2/7 inhibitor.
M6259 CP2 CP2 is a cyclic peptide that inhibits the JmjC histone demethylases KDM4 with IC50 values of 42 nM and 29 nM for KDM4A and KDM4C, respectively.
M6143 SP2509 SP2509 is a selective histone demethylase LSD1 inhibitor with IC50 of 13 nM, showing no activity against MAO-A, MAO-B, lactate dehydrogenase and glucose oxidase.
M5762 Mebhydrolin napadisylate Mebhydrolin (napadisylate) is an antihistamine, used for symptomatic relief of allergic symptoms caused by histamine release, including nasal allergies and allergic dermatosis.
M5213 ORY-1001 (Iadademstat) ORY-1001 (RG-6016) is the only dual KDM1A/LSD1 inhibitor, and it is also the only KDM1A inhibitor in development for the treatment of neurodegenerative disease.
M5212 GSK2879552 GSK2879552 is an effective, selective, bioactive and irreversible LSD1 inhibitor with Kiapp=1.7 μM.
M5149 GSK-J4 GSK-J4 is a cell permeable procompound rapidly hydrolyzed by macrophage esterases to GSK-J1, a potent selective jumonji H3K27 demethylase inhibitor.
M5136 GSK-LSD1 dihydrochloride GSK-LSD1 2HCl is an irreversible, and selective LSD1 inhibitor with IC50 of 16 nM, > 1000 fold selective over other closely related FAD utilizing enzymes (i.e. LSD2, MAO-A, MAO-B).
M2731 GSK-J4 hydrochloride GSK J4 hydrochloride is a cell permeable procompound of GSK J1, which is the first selective inhibitor of the H3K27 histone demethylase JMJD3 and UTX with IC50 of 60 nM and inactive against a panel of demethylases of the JMJ family.
M2730 GSK J1 GSK J1 is selective for the H3K27 demethylases JMJD3 (IC50=60 nM) and UTX.
M2275 JIB-04 JIB-04 is a selective inhibitor of Jumonji histone demethylase with IC50 values of 230, 340, 435, 445, 855 and 1100 nM for JARID1A, JMJD2E, JMJD2B, JMJD2A, JMJD3 and JMJD2C respectively.

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