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Histone demethylase Histone demethylase

Cat.No.  Name Information
M5149 GSK-J4 GSK-J4 is a cell permeable procompound rapidly hydrolyzed by macrophage esterases to GSK-J1, a potent selective jumonji H3K27 demethylase inhibitor.
M15089 PBIT PBIT is a JARID1 (Jumonji AT-Rich Interactive Domain 1) inhibitor with IC50 values of 3, 4.9 and 6 μM for JARID1B, 1A and 1C, respectively. It can increase trimethylation of H3K4 in HeLa cells and block the proliferation of tumor cells expressing high levels of JARID1B.
M13838 Seclidemstat mesylate Seclidemstat (SP-2577) mesylate is a potent noncompetitive and reversible KDM1A (LSD1) inhibitor (Ki=31 nM, IC50=13 nM).
M13832 GSK467 GSK467 is a cell penetrant and selective KDM5B (JARID1B or PLU1) inhibitor with a Ki of 10 nM, shows 180-fold selectivity for KDM4C and no measurable inhibitory effects toward KDM6 or other Jumonji family members.
M10921 GSK2879552 dihydrochloride GSK2879552 dihydrochloride is an oral, irreversible LSD1/KDM1A inhibitor with antitumor activity.
M10727 Pulrodemstat benzenesulfonate CC-90011 (Pulrodemstat) benzenesulfonate is a potent, selective, reversible and orally active lysine-specific demethylase-1 (LSD1) inhibitor,IC50 0.25 nM. CC-90011 benzenesulfonate has less enzymatic inhibition of LSD2, MOA-A and MAO-B. CC-90011 benzenesulfonate induces differentiation of acute myeloid leukemia (AML) and small cell lung cancer (SCLC) cells and has potent anti-cancer activity.
M10726 ORY-1001 (trans) Dihydrochloride, Iadademstat (ORY-1001) is an irreversible inhibitor of selective Lysine-specific demethylase 1A (KDM1A/LSD1).
M9689 Seclidemstat Seclidemstat is an orally active, reversible, noncompetitive inhibitor of lysine-specific demethylase 1 (LSD1, or KDM1A) with a mean IC50 of 127 nM, it has potential antineoplastic activity.
M9644 T-3775440 hydrochloride T-3775440 hydrochloride is a potent, selecitve, irreversible LSD1 inhibitor with IC50 value of 2.1 nM.
M9526 GSK-J5 GSK-J5 is a cell-permeable, inactive control for histone demethylase JMJD3/UTX inhibitor GSK-J4.
M9375 QC6352 QC6352 is a potent KDM4C inhibitor.
M8937 CPI-455 CPI-455 is a potent and selective inhibitor of KDM5 demethylases which reduces survival of cancer cells, with a half-maximal inhibitory concentration (IC50) of 10 ± 1 nM for full-length KDM5A in enzymatic assays.
M8409 ML324 ML324 is a potent JMJD2 demethylase inhibitor that is highly effective in reducing herpes simplex virus (HSV) IE gene expression.
M6831 IOX1 IOX1 is a histone demethylase inhibitor; cell permeable. IOX1 also inhibits ALKBH5.
M6650 Daminozide DaminoDaminozide is a plant growth regulator and selective inhibitor of human KDM2/7 histone demethylases, with IC50 values of 0.55, 1.5, and 2.1 μM for PHF8, KDM2A, and KIAA1718, respectively.Daminozide is >100-fold selective for KDM2/7 demethylases compared to other demethylase subfamily members tested. zide is a selective KDM2/7 inhibitor.
M6259 CP2 CP2 is a cyclic peptide that inhibits the JmjC histone demethylases KDM4 with IC50 values of 42 nM and 29 nM for KDM4A and KDM4C, respectively.
M6143 SP2509 SP2509 is A selective histone demethylase LSD1 inhibitor. SP2509 is also effective. It is A selective LSD1 antagonist with an IC50 of 13 nM and has no activity against MAO-A, MAO-B, lactate dehydrogenase and glucose oxidase.
M5762 Mebhydrolin napadisylate Mebhydrolin (napadisylate) is an antihistamine, used for symptomatic relief of allergic symptoms caused by histamine release, including nasal allergies and allergic dermatosis.
M5213 ORY-1001 (Iadademstat) ORY-1001 (RG-6016) is the only dual KDM1A/LSD1 inhibitor, and it is also the only KDM1A inhibitor in development for the treatment of neurodegenerative disease.
M5212 GSK2879552 GSK2879552 is an effective, selective, bioactive and irreversible LSD1 inhibitor with Kiapp=1.7 μM.

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