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GSK2879552 dihydrochloride

Cat. No. M10921
GSK2879552 dihydrochloride  Structure
Synonym:

GSK2879552 2HCl

Size Price Availability Quantity
5mg USD 85  USD85 In stock
10mg USD 132  USD132 In stock
50mg USD 420  USD420 In stock
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Quality Control & Documentation
Biological Activity

GSK2879552 dihydrochloride is an oral, irreversible LSD1/KDM1A inhibitor with antitumor activity.

Chemical Information
Molecular Weight 437.40
Formula C23H30Cl2N2O2
CAS Number 1902123-72-1
Solubility (25°C) Water ≥ 60 mg/mL
DMSO ≥ 30 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

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  Catalog
Abmole Inhibitor Catalog




Keywords: GSK2879552 dihydrochloride , GSK2879552 2HCl supplier, Histone demethylase, inhibitors, activators


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