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QC6352 is a potent KDM4C inhibitor. QC6352 blocks proliferation and self-renewal of BCSCs.
In vivo, QC6352 strongly affects tumor growth and final tumor weight of both BCSC1 and BCSC2 xenografts. Treatment with QC6352 is well tolerated and does not affect body weight of the mice. Results demonstrate that treatment with the KDM4 inhibitor QC6352 blocks BCSC xenograft tumor growth.
| Molecular Weight | 387.47 |
| Formula | C24H25N3O2 |
| CAS Number | 1851373-36-8 |
| Solubility (25°C) | DMSO ≥ 15 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[1] Metzger E, et al. Cancer Res. KDM4 Inhibition Targets Breast Cancer Stem-like Cells.
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