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IOX1

Cat. No. M6831
IOX1 Structure
Synonym:

IOX-1

Size Price Availability Quantity
10mg USD 100  USD100 In stock
50mg USD 350  USD350 In stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

IOX1 is a histone demethylase JMJD inhibitor (IC50 values are 0.12, 0.17, 0.2, 0.3, 0.6 and 1 μM for JMJD3, JMJD1A, JMJD2A, JMJD2E, JMJD2C and UTX respectively). IOX1 inhibits JMJD2A-mediated H3K9me3 demethylation in HeLa cells. IOX1 also inhibits ALKBH5.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 189.17
Formula C10H7NO3
CAS Number 5852-78-8
Purity >98%
Solubility DMSO: 15 mg/mL (Need ultrasonic and warming)
Storage at -20°C
References

[1] Fengling Li, et al. J Biomol Screen. A Radioactivity-Based Assay for Screening Human m6A-RNA Methyltransferase, METTL3-METTL14 Complex, and Demethylase ALKBH5

[2] Schiller R, et al. ChemMedChem. A cell-permeable ester derivative of the JmjC histone demethylase inhibitor IOX1.

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Keywords: IOX1, IOX-1 supplier, Histone demethylases, inhibitors

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