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IOX1

Cat. No. M6831

All AbMole products are for research use only, cannot be used for human consumption.

IOX1 Structure
Synonym:

IOX-1

Size Price Availability Quantity
1mg USD 33  USD33 In stock
5mg USD 57  USD57 In stock
10mg USD 83  USD83 In stock
50mg USD 295  USD295 In stock
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Quality Control & Documentation
Biological Activity

IOX1 is a histone demethylase JMJD inhibitor (IC50 values are 0.12, 0.17, 0.2, 0.3, 0.6 and 1 μM for JMJD3, JMJD1A, JMJD2A, JMJD2E, JMJD2C and UTX respectively). IOX1 inhibits JMJD2A-mediated H3K9me3 demethylation in HeLa cells. IOX1 also inhibits ALKBH5.

Chemical Information
Molecular Weight 189.17
Formula C10H7NO3
CAS Number 5852-78-8
Solubility (25°C) DMSO 13 mg/mL (ultrasonic and warming)
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Fengling Li, et al. J Biomol Screen. A Radioactivity-Based Assay for Screening Human m6A-RNA Methyltransferase, METTL3-METTL14 Complex, and Demethylase ALKBH5

[2] Schiller R, et al. ChemMedChem. A cell-permeable ester derivative of the JmjC histone demethylase inhibitor IOX1.

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Keywords: IOX1, IOX-1 supplier, Histone demethylase, inhibitors, activators

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