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IOX1

Cat. No. M6831
IOX1 Structure
Synonym:

IOX-1

Size Price Availability Quantity
5mg USD 75  USD75 In stock
10mg USD 100  USD100 In stock
50mg USD 350  USD350 In stock
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Quality Control & Documentation
Biological Activity

IOX1 is a histone demethylase JMJD inhibitor (IC50 values are 0.12, 0.17, 0.2, 0.3, 0.6 and 1 μM for JMJD3, JMJD1A, JMJD2A, JMJD2E, JMJD2C and UTX respectively). IOX1 inhibits JMJD2A-mediated H3K9me3 demethylation in HeLa cells. IOX1 also inhibits ALKBH5.

Chemical Information
Molecular Weight 189.17
Formula C10H7NO3
CAS Number 5852-78-8
Solubility (25°C) DMSO: 15 mg/mL (Need ultrasonic and warming)
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Fengling Li, et al. J Biomol Screen. A Radioactivity-Based Assay for Screening Human m6A-RNA Methyltransferase, METTL3-METTL14 Complex, and Demethylase ALKBH5

[2] Schiller R, et al. ChemMedChem. A cell-permeable ester derivative of the JmjC histone demethylase inhibitor IOX1.

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  Catalog
Abmole Inhibitor Catalog




Keywords: IOX1, IOX-1 supplier, Histone demethylase, inhibitors, activators


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