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About 30 results found for searched term "IOX1" (0.017 seconds)
| Cat.No. | Name | Information |
|---|---|---|
| M2057 | Dexrazoxane hydrochloride | Dexrazoxane HCl (ICRF-187, ADR-529, DXZ) is an iron chelator that can be used to prevent DOX-induced cardiotoxicity. |
| M2134 | Vortioxetine hydrobromide | Vortioxetine hydrobromide (Lu AA21004) is a 5-HT3, 5-HT7 and 5-HT1D receptor antagonist, a 5-HT1B receptor partial agonist, a 5-HT1A receptor agonist and a 5-HT transporter (5-HTT) inhibitor in vitro. |
| M2198 | Curcumin | Curcumin (Diferuloyl), a natural phenolic compound, is a p300/CREB binding protein specific inhibitor that inhibits histone/non-histone acetylation and histone acetyltransferase-dependent chromatin transcription. Curcumin inhibited NF-κ B and MAPKs, and had anti-inflammatory, antioxidant, anti-proliferation and anti-angiogenesis effects. Curcumin induces Nrf2 protein stabilization through Keap1 cysteine modification. |
| M2573 | IOX2 | IOX2 is a potent inhibitor of HIF-1α prolyl hydroxylase-2 (PHD2) with IC50 of 21 nM, >100-fold selectivity over JMJD2A, JMJD2C, JMJD2E, JMJD3, or the 2OG oxygenase FIH. |
| M3305 | Tioxolone | Tioxolone is a metalloenzyme carbonic anhydrase I inhibitor with a Ki of 91 nM. |
| M4058 | 11-oxo-mogroside-V | 11-Oxo-Mogroside V is a natural sweetener with strong antioxidant activity. 11-OXo-Mogroside V had a significant inhibitory effect on reactive oxygen species, and the EC50 of O2-, H2O2 and *OH were 4.79, 16.52 and 146.17 μg/mL, respectively. |
| M4062 | Punicalagin | Punicalagin is a species from Punica Granatum L. Or polyphenols isolated from the leaves of Terminalia catappa L. Punicalagin is a reversible, noncompetitive 3CLpro inhibitor that inhibits SARS-COV-2 replication in vitro. Punicalagin is an anti-hepatitis B virus (HBV) drug with antioxidant, anti-inflammatory and anticancer effects. Punicalagin has the potential to be used in COVID-19 research. |
| M4101 | Notoginsenoside-R1 | Notoginsenoside R1 (Sanchinoside R1) is a saponin isolated from P. notoginseng. Notoginsenoside R1 has antioxidant, anti-inflammatory, anti-angiogenic and anti-apoptotic activities. Notoginsenoside R1 provides cardiac protection against ischemia/reperfusion (I/R) injury. Notoginsenoside R1 may also provide neuroprotection. |
| M4123 | 10-Gingerol | 10-gingerol is one of the main irritant components of ginger root fat, which has anti-inflammatory, antioxidant and anti-proliferation activities. 10-gingerol inhibited the proliferation of MDA-MB-231 tumor cells with IC50 value of 12.1 μM. |
| M4355 | α-Mangostin | Alpha-mangostin is a dietary xanthone with broad biological activities, such as antioxidant, anti-allergic, antiviral, antibacterial, anti-inflammatory and anticancer effects. It is an inhibitor of mutant IDH1 (IDH1-R132H) with a Ki of 2.85 μM. |
| M4500 | Crocin-II | Crocin II, isolated from the fruit of Gardenia jasminoides, has antioxidant, anticancer and antidepressant activities. Crocin II inhibited NO production with IC50 value of 31.1 μM. Crocin II inhibited the expression of iNOS and COX-2 protein and M-RNA. |
| M4571 | Neohesperidin | Neohesperidin is an antioxidant agent with an IC50 of 22.31 μg/ml in the 1,1-diphenyl-2-picryldydrazyl (DPPH) radical-scavenging assay. |
| M4585 | Taxifolin (TFN) | Taxifolin (TFN) is an important natural compound with antifibrotic activity. Taxifolin is a free radical scavenger with antioxidant capacity. Taxifolin ((+)-Dihydroquercetin) exhibits important anti-tyrosinase activity. Taxifolin exhibits significant inhibitory activity against collagenase with an IC50 value of 193.3 μM. |
| M4597 | Silicristin | Silychristin is a flavonoid rich in milk thistle fruits, which has antioxidant effects. Silychristin is an effective inhibitor of thyroid hormone transporter MCT8 and can strongly inhibit T3 uptake with IC50 of 110 nM. |
| M4599 | Arbutin | Arbutin (β -arbutin) is a natural polyphenol isolated from the bear fruit plant Arctostaphylos uvaursi with antioxidant, anti-inflammatory and anti-tumor properties. It is a competitive inhibitor of tyrosinase in melanocytes, with a Kiapp value of 1.42 mM for monopholase. The value of p-diphenol enzyme Kiapp was 0.9 mM. Arbutin is also used as a bleaching agent. |
| M4686 | Eriodictyol | Eriodictyol is a flavonoid obtained from Chinese herbs, which has antioxidant and anti-inflammatory properties. Eriodictyol can induce Nrf2 signaling pathway. Eriodictyol is also an influenza dependent RNA polymerase inhibitor with an IC50 of 18 nM. |
| M4708 | Herbacetin | Herbacetin is a natural flavonoid found in flaxseed and has a variety of pharmacological activities, including antioxidant, anti-inflammatory and anticancer effects. Herbacetin is an Ornithine decarboxylase (ODC) allosteric inhibitor that binds directly to Asp44, Asp243 and Glu384 on ODC. It is also an SGK1 inhibitor. |
| M4746 | Isovitexin | Isovitexin, a flavonoid obtained from Asian rice seeds, has antioxidant and anti-inflammatory activities. Isovitexin acts like an inhibitor of JNK1/2 and inhibits NF-κB activation. |
| M4792 | Sinapine-thiocyanate | Sinapine, an alkaloid derived from seeds of the cruciferous species, possess antioxidant and radio-protective activities, downregulats multi-drug resistance 1 (MDR1) expression. Sinapine thiocyanate is also an acetylcholinesterase (AChE) inhibitor. |
| M4943 | 3,4,5-Trimethoxyphenylacetic acid | Cell suspensions did not release carbon dioxide from 3,4-[methoxyl-14C]dihydroxy-5-methoxyphenylacetate but accumulated 1 mol of methanol per mol of 3,4,5-trimethoxyphenylacetate oxidized. |
| M6058 | Vortioxetine | Vortioxetine (Lu AA21004) is a multimodal serotonergic agent, inhibits 5-HT1A, 5-HT1B, 5-HT3A, 5-HT7 receptor and SERT with IC50 of 15 nM, 33 nM, 3.7 nM, 19 nM and 1.6 nM, respectively. |
| M6136 | Epacadostat | Epacadostat (INCB024360) is a potent and selective indoleamine 2,3-dioxygenase (IDO1) inhibitor with IC50 of 10 nM and displays high selectivity over other related enzymes such as IDO2 or tryptophan 2,3-dioxygenase (TDO). |
| M6248 | BMS-986205 (Linrodostat) | BMS-986205 (Linrodostat) is a selective indoleamine 2,3-dioxygenase 1 (IDO1) inhibitor. |
| M6296 | Pyridoxine | Pyridoxine ((Pyridoxol, Vitamin B6, Gravidox)) is a pyridine derivative. Pyridoxine acts on alzheimer's disease cell models and exerts antioxidant effects through the NRF-2 /HO-1 pathway. |
| M6831 | IOX1 | IOX1 is a histone demethylase inhibitor; cell permeable. IOX1 also inhibits ALKBH5. |
| M7588 | N-acetylcysteine amide | N-Acetylcysteine amide is a thiol antioxidant and neuroprotective agent that crosses cell membranes and the blood-brain barrier, has anti-inflammatory activity, and is able to modulate NF-κB activation, HIF-1α and ROS. |
| M7596 | 4′-Aminomethyltrioxsalen hydrochloride | 4′-Aminomethyltrioxsalen hydrochloride is used to inactivate DNA and RNA viruses, including HIV-1, by nucleic acid cross-linking followed by UV irradiation. |
| M8395 | REDD1 inducer | 6-(1,3-Dioxo-6-(piperidin |
| M8642 | FINDY | FINDY is a cell-permeable thioxothiazolidinone derivative that specifically targets newly synthesized cellular DYRK1A, but not DYRK1B or DYRK2, for proteasomal degradation by suppressing DYKR1A intramolecular Ser97 autophosphorylation, a necessary event for folding/maturation of newly translated DYRK1A. |
| M9085 | Indoximod | Indoximod, also known as NLG8189 and D-1MT is an indoleamine 2,3-dioxygenase (IDO) pathway inhibitor with a Ki value of 19 μM. |
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