5,8-Epidioxyergosta-6,9(11),22-trien-3-ol (9,11-Dehydroergosterol peroxide), an important steroid from medicinal mushroom, exerts antitumor activity in several tumor types. 5,8-Epidioxyergosta-6,9(11),22-trien-3-ol inhibits HT29 cell growth by inducing CDKN1A expression, thus causing cell cycle arrest and apoptosis.
| Molecular Weight | 426.63 |
| Formula | C28H42O3 |
| CAS Number | 86363-50-0 |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
[1] C N Lin, et al. J Nat Prod. Novel cytotoxic principles of Formosan Ganoderma lucidum
| Related Apoptosis Products |
|---|
| Cytochrome C (from Pig Heart)
Cytochrome C (from Pig Heart) is a multifunctional enzyme involved in cellular life and death decisions.Cytochrome C is critical in mitochondrial electron transport and intrinsic type II apoptosis. |
| Celosin K
Celosin K, a triterpenoid saponin isolated from the seeds of Semen Celosiae, is also a potent inhibitor of t-BHP-induced neuronal damage. In addition, Celosin K inhibits oxidative stress, apoptosis, and autophagy. |
| GLP-2(rat)
GLP-2(rat) is an intestinal growth factor. |
| Edratide
Edratide (TV 4710) is a synthetic peptide of 19 amino acid based on the complementarity-determining region 1 (CDR1) of a human anti-DNA antibody that expresses a major idiotype denoted 16/6 Id. |
| Thrombospondin-1 (1016-1023) (human, bovine, mouse)
Thrombospondin-1 (1016-1023) (human, bovine, mouse), is the C-terminal end of the native sequence of Thrombospondin-1 (TSP-1), is a CD47 agonist peptide. |
Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2023 AbMole BioScience. All Rights Reserved.
