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KDM5-C70 

Cat. No. M28644

All AbMole products are for research use only, cannot be used for human consumption.

KDM5-C70  Structure
Size Price Availability Quantity
5mg USD 80  USD80 In stock
10mg USD 120  USD120 In stock
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Quality Control & Documentation
Biological Activity

KDM5-C70 is an ethyl ester derivative of KDM5-C49 and a potent, cell-permeable and pan-KDM5 histone demethylase inhibitor. KDM5-C70 has an antiproliferative effect in myeloma cells, leading to genome-wide elevation of H3K4me3 levels.

Chemical Information
Molecular Weight 336.43
Formula C17H28N4O3
CAS Number 1596348-32-1
Form Oil
Solubility (25°C) DMSO 100 mg/mL (ultrasonic)
Storage -20°C, sealed
References

[1] Manisha Deogharia, et al. bioRxiv. Histone demethylase KDM5 regulates cardiomyocyte maturation by promoting fatty acid oxidation, oxidative phosphorylation, and myofibrillar organization

[2] Ha-Rim Lee, et al. ACS Chem Neurosci. The KDM5 Inhibitor KDM5-C70 Induces Astrocyte Differentiation in Rat Neural Stem Cells

[3] Sarder Arifuzzaman, et al. Pharmacol Res. Research update and opportunity of non-hormonal male contraception: Histone demethylase KDM5B-based targeting

[4] Catrine Johansson, et al. Nat Chem Biol. Structural analysis of human KDM5B guides histone demethylase inhibitor development

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  Catalog
Abmole Inhibitor Catalog




Keywords: KDM5-C70  supplier, Histone demethylase, inhibitors, activators

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