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GSK-LSD1 dihydrochloride induces gene expression changes in cancer cell lines with average EC50 of < 5 nM and inhibits cancer cell line growth with average EC50 of < 5 nM.
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Source | Oncotarget (2017). Figure 4. GSK-LSD1 |
| Method | LDH activity assay | |
| Cell Lines | HSC-3 cells | |
| Concentrations | 1 and 10 μM | |
| Incubation Time | 24 and 48 hours | |
| Results | Thus, GSK-LSD1 inhibits EGF-induced signaling and proliferation without cytotoxicity in oral cancer cells. This represents a potential mechanism for the inhibitory effects of GSK-LSD1. |
| Molecular Weight | 289.24 |
| Formula | C14H22Cl2N2 |
| CAS Number | 2102933-95-7 |
| Solubility (25°C) | 50 mM in water 100 mM in DMSO |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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