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LRRK2-IN-1

Cat. No. M4949
LRRK2-IN-1 Structure
Size Price Availability Quantity
10mM*1mL USD 117  USD117 In stock
5mg USD 80  USD80 In stock
10mg USD 105  USD105 In stock
50mg USD 405  USD405 In stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

LRRK2-IN-1 is a cell-permeable, ATP competitive, potent, and selective LRRK2 inhibitor. IC50 is 13 nM, 6 nM, and 2.45 μM for wild type, G2019S mutant, and compound resistant A2016T mutant LRRK2, respectively.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 570.69
Formula C31H38N8O3
CAS Number 1234480-84-2
Purity >98%
Solubility 100 mM in DMSO
Storage at -20°C
References

[1] Hermanson SB,et.al. PLoS One Screening for novel LRRK2 inhibitors using a high-throughput TR-FRET cellular assay for LRRK2 Ser935 phosphorylation.

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Keywords: LRRK2-IN-1 supplier, LRRK2, inhibitors

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