About 27 results found for searched term "LRRK2" (0.141 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M4949 | LRRK2-IN-1 | LRRK2 |
| LRRK2-IN-1 is a potent and selective LRRK2 inhibitor with IC50 of 6 nM and 13 nM for LRRK2 (G2019S) and LRRK2 (WT), respectively. | ||
| M49508 | LRRK2/NUAK1/TYK2-IN-1 | LRRK2 |
| LRRK2/NUAK1/TYK2-IN-1 (conpound 226) shows inhibitory activity toward LRRK2 (Wt), LRRK2 (G2019), TYK2 and NUAK1, with IC50 values lower than 10 nM. | ||
| M49509 | LRRK2-IN-8 | LRRK2 |
| LRRK2-IN-8 is a LRRK2 inhibitor. | ||
| M3649 | GNE-7915 | LRRK2 |
| GNE-7915 is a highly potent, selective, and brain-penetrable leucine-rich repeat kinase 2 (LRRK2) inhibitor with IC50 and Ki of 9 nM and 1 nM, respectively. | ||
| M3795 | GNE-9605 | LRRK2 |
| GNE-9605 is a highly potent, selective, and brain-penetrant LRRK2 inhibitor with IC50 of 19 nM. | ||
| M3929 | PF-06447475 | LRRK2 |
| PF-06447475 is a highly potent, selective, brain penetrant LRRK2 inhibitor with IC0 of 3 nM/11 nM for Wt LRRK2/G2019S LRRK2 respectively. | ||
| M4831 | GSK2578215A | LRRK2 |
| GSK2578215A is a potent and selective LRRK2 kinase inhibitor with IC50 of 8.9 nM and 10.9 nM for LRRK2 (G2019S) and LRRK2 (WT), respectively. | ||
| M5204 | JH-II-127 | LRRK2 |
| JH-II-127 is a highly selective LRRK2 inhibitor with an IC50 = 6.5 nM. | ||
| M6649 | CZC-25146 | LRRK2 |
| CZC25146 | ||
| CZC 25146 is a potent and orally active LRRK2 inhibitor with IC50 values of 4.76 nM and 6.87 nM for wild-type LRRK2 and G2019S LRRK2, respectively. CZC-25146 inhibits PLK4, GAK, TNK1, CAMKK2 and PIP4K2C as well. | ||
| M8074 | PF-06454589 | Others |
| PF-06454589 is a potent and selective LRRK2 inhibitor. | ||
| M8313 | CZC-25146 hydrochloride | LRRK2 |
| CZC-25146 is a potent selective and metabolically stable inhibitor of leucine-rich repeat kinase-2 (LRRK2) also known as dardarin or PARK8, a kinase with mutations linked to Parkinson’s disease. | ||
| M9510 | JWG-071 | ERK |
| JWG-071 is the first reported kinase-selective chemical probe for ERK5, inhibits ERK5 and LRRK2 with IC50 of 88 and 109 nM, respectively. | ||
| M10452 | PFE-360 | LRRK2 |
| PF-06685360; PFE360 | ||
| PFE-360, also known as PF-06685360, is a potent and selective, brain penetrated inhibitor of LRRK2 kinase. | ||
| M10595 | MLi-2 | LRRK2 |
| MLi2 | ||
| MLi-2 is a highly potent, and selective LRRK2 kinase inhibitor with central nervous system activity. MLi-2 exhibits exceptional potency in a purified LRRK2 kinase assay in vitro (IC50 = 0.76 nM), a cellular assay monitoring dephosphorylation of LRRK2 pSer935 LRRK2 (IC50 = 1.4 nM), and a radioligand competition binding assay (IC50 = 3.4 nM). | ||
| M13572 | GNE0877 | LRRK2 |
| GNE0877 is a highly potent, selective, and brain-penetrant aminopyrazole leucine-rich repeat kinase 2 (LRRK2) small molecule inhibitor with an IC50 of 3 nM. | ||
| M13573 | GNE-7915 tosylate | LRRK2 |
| GNE-7915 tosylate is a potent, selective and brain-penetrant inhibitor of LRRK2 with an IC50 of 9 nM. | ||
| M13574 | HG-10-102-01 | LRRK2 |
| HG-10-102-01 is a potent and selective inhibitor of wild-type LRRK2(IC50=23.3 nM) and the G2019S mutant(IC50=3.2 nM). | ||
| M20140 | WAY-333491 | LRRK2 |
| WAY-333491 is a LRRK2 kinase inhibitor. | ||
| M20669 | CZC-54252 | LRRK2 |
| CZC-54252 is a potent and selective LRRK2 inhibitor with IC50s of 1.28 nM and 1.85 nM for human wild type LRRK2 and G2019S LRRK2, respectively. | ||
| M20811 | XMD8-85 (ERK5-IN-1) | ERK |
| XMD8-85 (ERK5-IN-1) is a selective and potent inhibitor of ERK5 and LRRK2 with IC50s of 0.162 μM and 0.339 μM, respectively. | ||
| M21292 | EB-42486 | LRRK2 |
| EB-42486 is a novel potent and highly selective inhibitor of G2019S-LRRK2 (IC50 < 0.2 nM). | ||
| M21588 | GSK2646264 | Syk |
| GSK2646264 is a potent and selective splenic tyrosine kinase (Syk) inhibitor with a pIC50 value of 7.1. GSK2646264 also inhibited other kinases, with pIC50 values of 5.4, 5.4, 5.3, 5, 4.5, <4.6 and <4.3 for LCK, LRRK2, GSK3β, JAK2, VEGFR2, Aurora B and Aurora A, respectively. GSK2646264 penetrates into the epidermis and dermis of the skin. | ||
| M28571 | PF-06455943 | LRRK2 |
| PF-06455943 is a leucine rich repeat kinase 2 (LRRK2) inhibitor with IC50 value of 3 nM. PF-06455943 also is a PET radioligand. PF-06455943 can be used for the research of ADME/neuro PK characterization and Parkinson disease (PD). | ||
| M28712 | PF-06371900 | LRRK2 |
| PF-06371900 is a potent and highly selective leucine rich repeat kinase 2 (LRRK2) inhibitor. | ||
| M41387 | JH-XII-03-02 | PROTAC |
| JH-XII-03-02 is a potent and selective LRRK2 PROTAC degrader. | ||
| M50171 | ARV-102 | PROTAC |
| ARV-102 is a PROTAC degrader targeting LRRK2 for studies related to Parkinson's disease (PD). | ||
| M58400 | CZC-54252 hydrochloride | LRRK2 |
| CZC-54252 HCl | ||
| CZC-54252 hydrochloride is a potent and selective LRRK2 inhibitor with IC50s of 1.28 nM and 1.85 nM for wild-type and G2019S LRRK2, respectively. | ||
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