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GNE-7915 tosylate

Cat. No. M13573
GNE-7915 tosylate Structure
Size Price Availability
5mg USD 60  USD60 Out of stock
10mg USD 90  USD90 Out of stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

GNE-7915 tosylate is a potent, selective and brain-penetrant inhibitor of LRRK2 with an IC50 of 9 nM.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 615.6
Formula
CAS Number 2070015-00-6
Purity >99%
Solubility DMSO ≥ 50 mg/mL
Storage 2-8°C, dry, sealed
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  Catalog
Abmole Inhibitor Catalog




Keywords: GNE-7915 tosylate supplier, LRRK2, inhibitors

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