LRRK2 Leucine-rich repeat kinase 2

Inhibitors

Cat.No.	Name	Information
M10595	MLi-2	MLi-2 is a highly potent, and selective LRRK2 kinase inhibitor with central nervous system activity. MLi-2 exhibits exceptional potency in a purified LRRK2 kinase assay in vitro (IC50 = 0.76 nM), a cellular assay monitoring dephosphorylation of LRRK2 pSer935 LRRK2 (IC50 = 1.4 nM), and a radioligand competition binding assay (IC50 = 3.4 nM).
M10452	PFE-360	PFE-360, also known as PF-06685360, is a potent and selective, brain penetrated inhibitor of LRRK2 kinase.
M6649	CZC 25146	CZC 25146 is a potent LRRK2 inhibitor.
M5204	JH-II-127	JH-II-127 is a highly selective LRRK2 inhibitor with an IC50 = 6.5 nM.
M4949	LRRK2-IN-1	LRRK2-IN-1 is useful in treatment of Parkinson's disease.
M4831	GSK2578215A	GSK2578215A is a potent and selective LRRK2 kinase inhibitor with IC50 of 8.9 nM and 10.9 nM for LRRK2 (G2019S) and LRRK2 (WT), respectively.
M3929	PF-06447475	PF-06447475 is a highly potent, selective, brain penetrant LRRK2 inhibitor with IC0 of 3 nM/11 nM for Wt LRRK2/G2019S LRRK2 respectively.
M3795	GNE-9605	GNE-9605 is a highly potent, selective, and brain-penetrant LRRK2 inhibitor with IC50 of 19 nM.
M3649	GNE-7915	GNE-7915 is a highly potent, selective, and brain-penetrable leucine-rich repeat kinase 2 (LRRK2) inhibitor with IC50 and Ki of 9 nM and 1 nM, respectively.