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PFE-360

Cat. No. M10452
PFE-360 Structure
Synonym:

PF-06685360; PFE360

Size Price Availability Quantity
2mg USD 220  USD220 In stock
5mg USD 330  USD330 In stock
10mg USD 490  USD490 In stock
50mg USD 1220  USD1220 In stock
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Quality Control
  • Current batch:
  • Purity >98.5%
  • COA
  • MSDS
Biological Activity

PFE-360, also known as PF-06685360, is a potent and selective, brain penetrated inhibitor of LRRK2 kinase. PFE-360 (PF-06685360) has a mean IC50 of 2.3 nM in vivo.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 308.34
Formula C16H16N6O
CAS Number 1527475-61-1
Purity >98.5%
Solubility DMSO 7 mg/mL
Storage at -20°C
References

[1] Michael Aagaard Andersen, et al. Neurobiol Dis. Parkinson's disease-like burst firing activity in subthalamic nucleus induced by AAV-α-synuclein is normalized by LRRK2 modulation

[2] Michael Aagaard Andersen, et al. Toxicology. PFE-360-induced LRRK2 inhibition induces reversible, non-adverse renal changes in rats

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Keywords: PFE-360, PF-06685360; PFE360 supplier, LRRK2, inhibitors

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