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CZC-54252 hydrochloride is a potent and selective LRRK2 inhibitor with IC50s of 1.28 nM and 1.85 nM for wild-type and G2019S LRRK2, respectively. CZC-54252 hydrochloride has a neuroprotective activity.
| Molecular Weight | 541.45 |
| Formula | C22H26Cl2N6O4S |
| CAS Number | 1784253-05-9 |
| Form | Solid |
| Solubility (25°C) | DMSO 30 mg/mL |
| Storage | 4°C, dry, sealed |
| Related LRRK2 Products |
|---|
| PF-06371900
PF-06371900 is a potent and highly selective leucine rich repeat kinase 2 (LRRK2) inhibitor. |
| PF-06455943
PF-06455943 is a leucine rich repeat kinase 2 (LRRK2) inhibitor with IC50 value of 3 nM. PF-06455943 also is a PET radioligand. PF-06455943 can be used for the research of ADME/neuro PK characterization and Parkinson disease (PD). |
| CZC-25146 hydrochloride
CZC-25146 is a potent selective and metabolically stable inhibitor of leucine-rich repeat kinase-2 (LRRK2) also known as dardarin or PARK8, a kinase with mutations linked to Parkinson’s disease. |
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