About 32 results found for searched term "Tec-IN-1" (0.078 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M30438 | Protectin D1 | Metabolite/Endogenous Metabolite |
| Neuroprotectin D1; NPD1 | ||
| Protectin D1, neuroprotectin D1 when generated by neural cells, is a member of a new family of bioactive products generated from docosahexaenoic acid. Protectin D1 is also a specialized pro-resolving mediator with potent pro-resolving and anti-inflammatory effects in vivo in several human disease models. | ||
| M42621 | Tec-IN-1 | Tyrosinase |
| Tec-IN-1 is a Tec inhibitor (IC50s of 11.7 μM). | ||
| M2558 | DMOG | HIF |
| Dimethyloxallyl Glycine | ||
| DMOG (Dimethyloxaloyl glycine) is an antagonist of α-ketoglutarate cofactor and a cell permeable and competitive inhibitor of HIF-PH, which results in HIF-1α stabilisation and accmulation in vitro and in vivo. DMOG acts as a pro-angiogenic agent and plays a protective role in experimental model of colitis and diarrhoea via HIF-1 related signal. DMOG induces cell autophagy. | ||
| M3400 | Idebenone | Ferroptosis |
| CV-2619 | ||
| Idebenone, a mitochondrial protector, has neuroprotective properties and can be used to study Alzheimer's disease, Huntington's disease, and can cross the blood-brain barrier. Idebenone (oxidized form) inhibited arachidonic acid enzyme metabolism in astrocyte homogenates (IC50=16.65 μM). Idebenone is a coenzyme Q10 analogue and antioxidant that induces apoptosis (apoptotic) in human dopaminergic neuroblastoma SHSY-5Y cells. | ||
| M3895 | Liquiritin | ROS |
| Liquiritin is a major constituent of Glycyrrhiza Radix that has a neuroprotective effect against glutamate toxicity in DPC12 cells. | ||
| M3915 | Catechin | COX |
| (+)-Catechin; Cianidanol | ||
| Catechin (Cianidanol) is a flavan-3-ol, a type of natural phenol and antioxidant. Catechin ((+)-Catechin) inhibits cyclooxygenase-1 (COX-1) with an IC50 of 1.4 μM. | ||
| M4011 | Echinatin | Others |
| Echinatin is isolated from the Chinese herbal medicine licorice, chalcone, which has liver protection and anti-inflammatory effects. In rats, Echinatin can be rapidly absorbed and eliminated and is widely distributed, with an absolute bioavailability of about 6.81%. | ||
| M4093 | Panaxadiol | PD-1/PD-L1 |
| 20(R)-Panaxadiol | ||
| Panaxadiol exists in ginseng root and has neuroprotective and anti-tumor functions. Panaxadiol inhibits the expression of programmed cell death ligand-1 (PD-L1) and tumor proliferation. | ||
| M4101 | Notoginsenoside-R1 | Amyloid |
| Sanchinoside R1; Sanqi glucoside R1 | ||
| Notoginsenoside R1 (Sanchinoside R1) is a saponin isolated from P. notoginseng. Notoginsenoside R1 has antioxidant, anti-inflammatory, anti-angiogenic and anti-apoptotic activities. Notoginsenoside R1 provides cardiac protection against ischemia/reperfusion (I/R) injury. Notoginsenoside R1 may also provide neuroprotection. | ||
| M4207 | (-)Epicatechin | COX |
| (-)-Epicatechol; Epicatechin; epi-Catechin | ||
| Epicatechin inhibited coX-1 with IC50 of 3.2 μM. (-)Epicatechin inhibits il-1 β -induced iNOS expression by blocking nuclear localization of NF-κB p65 subunit. | ||
| M4212 | CG | COX |
| (-)-Catechin 3-gallate; (-)-Catechin 3-O-gallate | ||
| (-) -catechin gallate is a microcomponent of green tea Catechin. (-) -catechin gallate inhibited COX-1 and COX-2 activities. | ||
| M4428 | Senkyunolide-I | Caspase |
| Senkyunolide I can be isolated from Ligusticum chuanxiong Hort and is an antimigraine compound. Senkyunolide I protects rat brain from focal cerebral ischemia-perfusion injury by up-regulating P-ERK1/2, Nrf2/HO-1 and inhibiting Caspase 3. | ||
| M4443 | Spinosin | Amyloid |
| Spinosyn is a neuroprotective C-glycoside flavonoid isolated from the seeds of Zizyphus jujube. Spinosyn inhibits the production and polymerization of Aβ1-42 by activating the Nrf2/HO-1 pathway. | ||
| M4465 | Irinotecan | Topoisomerase |
| (+)-Irinotecan; CPT-11; VAL-413 | ||
| Irinotecan is an inhibitor of Topoisomerase I, preventing religation of the DNA strand by binding to topoisomerase I-DNA complex. Irinotecan inhibits the growth of LoVo and HT-29 cells, with IC50s of 15.8 ± 5.1 and 5.17 ± 1.4 μM, respectively. | ||
| M4511 | Tectorigenin | Apoptosis |
| Tectorigenin is a plant isoflavonoid originally isolated from the dried flower of Pueraria thomsonii Benth. Tectorigenin attenuates enhanced IKKβ phosphorylation and effectively blocks NF-κB activation by inhibition of p65 phosphorylation at concentrations ranging from 0.1 to 10 μM. | ||
| M4528 | Rosarin | IL Receptor/Related |
| Rosarin is a cinnamyl glycoside isolated from rhodiola rosea. Rosarin has anti-inflammatory and neuroprotective effects. Rosarin inhibited the expression of iNOS, IL-1β and TNF-α in the kidney and prefrontal cortex of mice. | ||
| M4552 | Nobiletin | Autophagy |
| Nobiletin is a citrus flavonoid with anti-inflammatory, anti-cancer, cholesterol lowering, memory protection activities. Nobiletin is a retinoid acid receptor-related orphan receptors (RORs) agonist. Nobiletin can reduce reactive oxygen species (ROS) levels in differentiated C2C12 myotubes. | ||
| M5590 | Dopamine HCl | Dopamine Receptor |
| ASL279; Dopamine hydrochloride | ||
| Dopamine HCl is a catecholamine neurotransmitter present in a wide variety of animals,And a dopamine D1-5 receptors agonist. Dopamine hydrochloride (ASL279) plays several important roles in the brain and body. Dopamine hydrochloride (ASL279) acts through D2 dopamine receptors to induce endocytosis of VEGFR2, which is critical for promoting angiogenesis. | ||
| M5711 | Irinotecan hydrochloride | Topoisomerase |
| CPT-11 HCl | ||
| Irinotecan hydrochloride ((+)-Irinotecan hydrochloride) is a topoisomerase I inhibitor. Irinotecan prevents DNA from unwinding by inhibition of topoisomerase 1. | ||
| M6206 | ARV-825 | Epigenetic Reader Domain |
| ARV-825 is a BRD4 Inhibitor based on PROTAC technology. ARV-825 shows affinity to BD1 and BD2 of BRD4 with Kds of 90 and 28 nM, respectively. | ||
| M7534 | SSR240612 | Bradykinin Receptor |
| Treatment with the kinin B1 receptor antagonist, SSR240612, provided a protective effect against organ damage by interfering with multiple target functions, including the suppression of B1R-induced inflammation and platelet aggregation. | ||
| M7588 | N-acetylcysteine amide | NF-κB |
| N-Acetylcysteine amide is a thiol antioxidant and neuroprotective agent that crosses cell membranes and the blood-brain barrier, has anti-inflammatory activity, and is able to modulate NF-κB activation, HIF-1α and ROS. | ||
| M7647 | Bryostatin 1 | PKC |
| Bryostatin 1 is a natural macrolide isolated from the moss bug Bugula neritina and a potent PKC modulator of central nervous system (CNS) permeability.Bryostatin 1 binds to the isolated Munc13-1 C1 domain and the full-length Munc13-1 protein with a Ki value of 8.07 and 0.45 nM, respectively, and has anticancer, anti-inflammatory and neuroprotective activities. Bryostatin 1 binds to the isolated C1 domain of Munc13-1 and the full-length Munc13-1 protein with Ki values of 8.07 nM and 0.45 nM, respectively, and exhibits anticancer, anti-inflammatory, and neuroprotective activities. | ||
| M8327 | D,L-Metanephrine hydrochloride | TAAR |
| Metanephrine is an endogenous metabolite of epinephrine, formed by catechol-O-methyltransferase activity, as well as a biomarker of cancer and can be used to diagnose pheochromocytoma. In addition, Metanephrine is a potent agonist of the trace amine-associated receptor TAAR1. | ||
| M9604 | Kinsenoside | Keap1-Nrf2 |
| Kinsenoside is a main active component isolated from plants of the genus Anoectochilus, and exhibits many biological activities and pharmacological effects. Kinsenoside and Nrf2 depend on the protection of nuclear cells (NPCs), which significantly reduces their ability to survive. Kinsenoside Active NPC Medium AKT-ERK1/2-Nrf2 Signal passage, Prevent physical decline, aging, harmonious physical function impairment. | ||
| M10396 | Deruxtecan | Drug-Linker Conjugates for ADC |
| Deruxtecan is an ADC drug-linker conjugate composed of a derivative of DX-8951 (DXd) and a maleimide-GGFG peptide linker, used for synthesizing DS-8201 and U3-1402. | ||
| M10708 | Indotecan | Topoisomerase |
| LMP-400 | ||
| Indotecan (LMP-400) is a potent topoisomerase 1 (Top1) inhibitor. Indotecan (LMP-400) for P388, HCT116, MCF-7 cell linesIC50 The values are 300, 1200, 560 nM, respectively. | ||
| M10989 | (+)-Catechin hydrate | COX |
| (+)-Catechin hydrate inhibits cyclooxygenase-1 (COX-1), with IC50 of 1.4 μM. | ||
| M11001 | COG-1410 TFA | Apoptosis |
| COG1410 is a peptide derived from apolipoprotein E. COG1410 plays a neuroprotective and anti-inflammatory role in a mouse brain injury (TBI) model. COG1410 can be used in the study of neurological diseases. | ||
| M11127 | Sanggenol A | Others |
| Sanggenol A shows neuroprotective activity on glutamate-induced cell death in HT22 cells, with EC50 values of 34.03 ± 7.71 μM. Sanggenol A inhibits influenza A viral and pneumococcal neuraminidase (NA), it also disrupts the synergism between influenza A virus and pneumococcal NA in vitro, hence functioning as dual-acting anti-infectives. | ||
| M11394 | Felypressin | Vasopressin Receptor |
| PLV-2 | ||
| Felypressin (PLV-2) is a non-catecholamine vasoconstrictor and a vasopressin 1 (Vasopressin 1) agonist. Felypressin is widely used in dental surgery. | ||
| M11431 | Poseltinib | BTK |
| HM71224; LY3337641 | ||
| Poseltinib is an orally active, selective, irreversible small-molecule Bruton tyrosine kinase (BTK) inhibitor with an IC50 of 1.95 nM and 0.3, 2.3, and 2.4 fold selective action against BMX, TEC, and TXK, respectively. Poseltinib covalently binds to the active site of BTK (cysteine 481 residue) and effectively inhibits B cell receptor (BCR), Fc receptor (FcR), and Toll-like receptor (TLR) mediated signaling. | ||
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