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Treatment with the kinin B1 receptor antagonist, SSR240612, provided a protective effect against organ damage by interfering with multiple target functions, including the suppression of B1R-induced inflammation and platelet aggregation.
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Preparation method | |
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Animal models | C57BL/6J mice |
Formulation | |
Dosages | 10 mg/kg |
Administration | gavage |
Molecular Weight | 793.41 |
Formula | C42H53ClN4O7S |
CAS Number | 464930-42-5 |
Form | Solid |
Solubility (25°C) | 10 mM in DMSO |
Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
Related Bradykinin Receptor Products |
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[Hyp3]-Bradykinin
[Hyp3]-Bradykinin, naturally occurring peptide hormone, is a bradykinin receptor agonist. |
Bradykinin (1-6)
Bradykinin (1-6) is an amino-truncated Bradykinin peptide. |
Lys-[Des-Arg9]Bradykinin TFA
Lys-[Des-Arg9]Bradykinin TFA, a naturally occurring kinin, is a potent and highly selective bradykinin B1 receptor agonist with a Ki of 0.12 nM, 1.7 nM and 0.23 nM for human, mouse and rabbit B1 receptors, respectively. |
Lobradimil
Lobradimil (RMP 7), a synthetic bradykinin analog, is a potent and selective bradykinin B2 receptor agonist (Ki: 0.54 nM). |
[Tyr8] Bradykinin
[Tyr8] Bradykinin is a B2 kinin receptor agonist. |
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