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Icatibant

Cat. No. M13916
Icatibant Structure
Synonym:

HOE 140

Size Price Availability Quantity
5mg USD 520  USD520 In stock
10mg USD 770  USD770 In stock
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Quality Control & Documentation
Biological Activity

Icatibant (HOE-140) is a potent and specific peptide antagonist of bradykinin B2 receptor with IC50 and Ki of 1.07 nM and 0.798 nM respectively.

Chemical Information
Molecular Weight 1304.52
CAS Number 130308-48-4
Form Solid
Solubility (25°C) Water 90 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Jinyoung Jeon, et al. Effect of icatibant on angiotensin-converting enzyme inhibitor-induced angioedema: A meta-analysis of randomized controlled trials

[2] Sabrina W Cole, et al. Icatibant for the treatment of hereditary angioedema

[3] Eline A Dubois, et al. Icatibant

[4] Jordi Gras. Icatibant for hereditary angioedema

[5] Emma D Deeks. Icatibant

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Keywords: Icatibant, HOE 140 supplier, Bradykinin Receptor, inhibitors, activators


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