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Bradykinin (bradykinin) is a vasodilator active peptide produced by the kinin-releasing enzyme-kinin system that modulates inflammation by causing vasodilation, increasing vascular permeability, and stimulating prostaglandin synthesis.
| Cell Experiment | |
|---|---|
| Cell lines | H9C2 cells |
| Preparation method | H9C2 cells, 24 hours after seeding in 12-well plates, were exposed to various concerntrations of H2O2 to induce DNA damage and senescence. After 2 hours, the medium was replaced with normal medium. BK with different kinds of concentrations was given 30 minutes before the induction of senescence. The B2R antagonist HOE-140 (1 µmol/l) and eNOS inhibitor Nω-methyl-L-arginine acetate salt (L-NAME) (10 µmol/l) were added 5 minutes before BK treatment, after which BK was added without replacing the medium. 24 hours after H2O2 treatment, H9C2 cells were harvested for senescence determination. At least 3 separate experiments were performed per treatment. |
| Concentrations | 1 pM-10 nM |
| Incubation time | 24 h |
| Animal Experiment | |
|---|---|
| Animal models | Male Swiss mice |
| Formulation | Physiological saline |
| Dosages | 2, 4 and 8 μg/mice |
| Administration | Intraplantar injection |
| Molecular Weight | 1060.21 |
| CAS Number | 58-82-2 |
| Form | Solid |
| Solubility (25°C) | Water ≥ 90 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[2] M Maurer, et al. New topics in bradykinin research
[3] R M Burch, et al. Bradykinin receptor antagonists
| Related Bradykinin Receptor Products |
|---|
| [Hyp3]-Bradykinin
[Hyp3]-Bradykinin, naturally occurring peptide hormone, is a bradykinin receptor agonist. |
| Bradykinin (1-6)
Bradykinin (1-6) is an amino-truncated Bradykinin peptide. |
| Lys-[Des-Arg9]Bradykinin TFA
Lys-[Des-Arg9]Bradykinin TFA, a naturally occurring kinin, is a potent and highly selective bradykinin B1 receptor agonist with a Ki of 0.12 nM, 1.7 nM and 0.23 nM for human, mouse and rabbit B1 receptors, respectively. |
| Lobradimil
Lobradimil (RMP 7), a synthetic bradykinin analog, is a potent and selective bradykinin B2 receptor agonist (Ki: 0.54 nM). |
| [Tyr8] Bradykinin
[Tyr8] Bradykinin is a B2 kinin receptor agonist. |
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