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Icatibant (HOE 140) acetate

Cat. No. M10164

All AbMole products are for research use only, cannot be used for human consumption.

Icatibant (HOE 140) acetate Structure
Synonym:

HOE 140 acetate

Size Price Availability Quantity
5mg USD 240  USD240 In stock
10mg USD 380  USD380 In stock
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Biological Activity

Icatibant (HOE-140) acetate is a potent and specific peptide antagonist of bradykinin B2 receptor, with IC50 value of 1.07 nM and Ki value of 0.798 nM, respectively. Icatibant (0.3 or 1.5 mg/kg; subcutaneous administration twice daily) in mice shows a significant preventive effect on ulcerative Colitis.

Chemical Information
Molecular Weight 1364.57
Formula C61H93N19O15S
CAS Number 138614-30-9
Form Solid
Solubility (25°C) Water 45 mg/mL
Storage -20°C, sealed, protect from light
References

[1] Marie-Therese Bawolak, et al. Eur J Pharmacol. The bradykinin B2 receptor antagonist icatibant (Hoe 140) blocks aminopeptidase N at micromolar concentrations: off-target alterations of signaling mediated by the bradykinin B1 and angiotensin receptors

[2] Y Arai, et al. Dig Dis Sci. Effect of icatibant, a bradykinin B2 receptor antagonist, on the development of experimental ulcerative colitis in mice

[3] F J Hock, et al. Br J Pharmacol. Hoe 140 a new potent and long acting bradykinin-antagonist: in vitro studies

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