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ELN 441958

Cat. No. M3947

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ELN 441958 Structure
Size Price Availability Quantity
10mM*1mL in DMSO USD 300  USD300 In stock
5mg USD 265  USD265 In stock
10mg USD 430  USD430 In stock
25mg USD 850  USD850 In stock
50mg USD 1350  USD1350 In stock
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Quality Control & Documentation
Biological Activity

ELN-441958 is a potent, neutral, competitive and selective oral bioavailable bradykinin B1 receptor antagonist with a Ki of 0.26 nM against native human bradykinin B1 receptor.

ELN-441958 (1-10 mg/kg; s.c.; once) dose-dependently reduces carrageenan-induced thermal hyperalgesia in a rhesus monkey tail-withdrawal model. ELN-441958 (0-10 mg/kg; i.v. or p.o.) exhibits a favorable pharmacokinetic profile in the rat and rhesus monkey.

Chemical Information
Molecular Weight 501.02
Formula C29H29ClN4O2
CAS Number 913064-47-8
Form Solid
Solubility (25°C) DMSO 100 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
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Keywords: ELN 441958 supplier, Bradykinin Receptor, inhibitors, activators

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