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-Catechin hydrate.gif)
(+)-Catechin hydrate inhibits cyclooxygenase-1 (COX-1), with IC50 of 1.4 μM.
A dose-dependent reduction in color is observed after 24 hours of treatment with (+)-Catechin, and 54.76% of the cells are dead at the highest concentration of (+)-Catechin tested (160 μg/mL) whereas the IC50 of (+)-Catechin is achieved at 127.62 μg/mL (+)-Catechin. A dose- and time-dependent increase in the induction of apoptosis is observed when MCF-7 cells are treated with (+)-Catechin. When compare to the control cells at 24 hours, 40.7 and 41.16% of the cells treated with 150 μg/mL and 300 μg/mL (+)-Catechin, respectively, undergo apoptosis.
Animals treated with (+)-Catechin at the lowest tested dose, i.e., 50 mg/kg, p.o. have spent comparatively more time in exploring the novel object in the choice trial, however, the difference is not statistically significant. (+)-Catechin prevents the time-induced episodic memory deficits in a dose-dependent manner, the most effective being 200 mg/kg, p.o.. Treatment with (+)-Catechin prevents the rise in MPO level compare to DOX alone treatment group.
| Molecular Weight | 308.29 |
| Formula | C15H16O7 |
| CAS Number | 225937-10-0 |
| Solubility (25°C) | DMSO 45 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related COX Products |
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| Firocoxib
Firocoxib is a selective COX-2 inhibitor exhibiting high selectivity to inhibit COX-2. |
| Ampiroxicam
Ampiroxicam is a nonselective cyclooxygenase inhibitor uesd as anti-inflammatory compound. |
| Bufexamac
Bufexamac is a COX inhibitor for IFN-α release with EC50 of 8.9 μM. |
| Carprofen
Carprofen inhibits canine COX2 with IC50 of 0.03 mM. |
| Diclofenac Diethylamine
Diclofenac diethylamine is a nonsteroidal anti-inflammatory compound taken to reduce inflammation and as an analgesic reducing pain in certain conditions. |
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