Free shipping on all orders over $ 500

(+)-Catechin hydrate

Cat. No. M10989
(+)-Catechin hydrate  Structure
Size Price Availability Quantity
100mg USD 50  USD50 In stock
200mg USD 70  USD70 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control & Documentation
Biological Activity

(+)-Catechin hydrate inhibits cyclooxygenase-1 (COX-1), with IC50 of 1.4 μM. 

A dose-dependent reduction in color is observed after 24 hours of treatment with (+)-Catechin, and 54.76% of the cells are dead at the highest concentration of (+)-Catechin tested (160 μg/mL) whereas the IC50 of (+)-Catechin is achieved at 127.62 μg/mL (+)-Catechin. A dose- and time-dependent increase in the induction of apoptosis is observed when MCF-7 cells are treated with (+)-Catechin. When compare to the control cells at 24 hours, 40.7 and 41.16% of the cells treated with 150 μg/mL and 300 μg/mL (+)-Catechin, respectively, undergo apoptosis. 

Animals treated with (+)-Catechin at the lowest tested dose, i.e., 50 mg/kg, p.o. have spent comparatively more time in exploring the novel object in the choice trial, however, the difference is not statistically significant. (+)-Catechin prevents the time-induced episodic memory deficits in a dose-dependent manner, the most effective being 200 mg/kg, p.o.. Treatment with (+)-Catechin prevents the rise in MPO level compare to DOX alone treatment group.

Chemical Information
Molecular Weight 308.29
Formula C15H16O7
CAS Number 225937-10-0
Solubility (25°C) DMSO 45 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Dan Li, et al. Autophagy. Sulforaphane Activates a lysosome-dependent transcriptional program to mitigate oxidative stress

[2] Amita Rai, et al. Andrologia. Assessment of preclinical effect of (+)-catechin hydrate on sexual function: An in silico and in vivo study

[3] Samah A Khattab, et al. Toxicol Mech Methods. Effects of catechin hydrate in benzo[ a]pyrene-induced lung toxicity: roles of oxidative stress, apoptosis, and DNA damage

Related COX Products
Birch triterpenes

Birch triterpenes is a cyclooxygenase-2 (COX-2) inhibitor that can be used in studies related to epidermolysis bullosa.

Naproxcinod

Naproxcinod is a first-of-its-kind (first-in-class) cyclooxygenase-inhibiting nitric oxide donors (CINODs) with analgesic and anti-inflammatory activity for studies related to osteoarthritis and inflammation.

Hamaudol

Hamaudol is a chromone isolated from Saposhnikovia divaricata.

(±)-Catechin

(±)-Catechin (rel-Cianidanol) is the racemate of Catechin.

PYZ18

PYZ18 is a selective COX-2 inhibitor with an IC50 of 7.07 μM.

  Catalog
Abmole Inhibitor Catalog




Keywords: (+)-Catechin hydrate supplier, COX, inhibitors, activators


Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2023 AbMole BioScience. All Rights Reserved.