About 30 results found for searched term "SKI-V" (0.101 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M21034 | SKI-V | SPHK |
| SKI V is a noncompetitive and potent inhibitor of non-lipid sphingosine kinase with IC50 of 2 μM for GST-hSK. SKI-V also inhibits PI3K with IC50 of 6 μM for hPI3k. SKI-V decreases formation of the mitogenic second messenger sphingosine-1-phosphate (S1P) and induces apoptosis with antitumor activity. | ||
| M1685 | Bosutinib | Src-bcr-Abl |
| SKI-606 | ||
| Bosutinib (SKI-606) is a novel Bcr-Abl inhibitor with IC50 values of 0.1 to 0.3 umol/L. | ||
| M2842 | Methoxamine hydrochloride | Adrenergic Receptor |
| Vasoxine HCl | ||
| Methoxamine is an α1-adrenergic receptor agonist, it induces vasoconstriction of skin and splanchnic blood vessels. | ||
| M3012 | SKI II | S1P Receptor |
| SphK-I2 | ||
| SKI II is a highly selective and non ATP-competitive S1P receptor inhibitor with IC50 of 0.5 μM, while exhibits no inhibitory on other kinases including PI3K, PKCα and ERK2. | ||
| M3973 | Tazarotene | RAR/RXR |
| Tazorac; Zorac; AGN 190168 | ||
| Tazarotene (AGN 190168) is a new member of the acetylenic class of RARβ/γ selective retinoids which is approved to treat a variety of skin diseases, exhibits an anti-proliferative effect in human basal cell carcinoma (BCC) by triggering caspase-dependent apoptosis. | ||
| M4567 | Escin-IB | Others |
| Escin IB is a saponin isolated from the skin and endosperm of horse chestnut (Aesculus hippocastanum) seeds. Escin IB has an inhibitory effect on pancreatic lipase activity. | ||
| M4922 | Cloxiquine | Antibiotic |
| 5-Chloro-8-quinolinol; Dermofungin | ||
| Cloxiquine (5-chloro-8-quinolinol) has antibacterial, anti-fungal and anti-amoeba properties. Cloxiquine could be used to study tuberculosis and skin diseases. Cloxiquine also inhibits the growth and metastasis of melanoma cells by activating PPARγ. | ||
| M5365 | Monobenzone | Animal Modeling |
| 4-(Benzyloxy)phenol | ||
| Monobenzone is a potent skin depigmenting agent that specifically inhibits tyrosinase and can be used in the construction of animal models of vitiligo and in studies related to skin pigmentation loss. | ||
| M5636 | Etretinate | Apoptosis |
| Tegison, Ethyl etrinoate, Retinoid, Etretinato | ||
| Etretinate is an orally available aromatic retinoid that has been shown to be effective in studies of cow skin and other skin syndromes. It can activate retinoid receptor, induce cell differentiation, inhibit cell proliferation and inhibit tissue infiltration. | ||
| M6133 | Oritavancin diphosphate | Antibiotic |
| LY 333328 diphosphate | ||
| Oritavancin is approved for the treatment of adult patients with acute bacterial skin and skin structure infections (SSSIs) caused by or suspected to be caused by susceptible isolates of designated gram-positive microorganisms. | ||
| M8194 | SKI 5C | Others |
| SKI 5C is a selective Sphingosine Kinase 1 (SPHK1) inhibitor. | ||
| M8980 | Neticonazole Hydrochloride | Anti-infection |
| Neticonazole HCl | ||
| Neticonazole Hydrochloride is an imidazole antifungal for the treatment of fungal skin infections, Neticonazole is reported as a potent exosome inhibitor which can block the activity of exosomes. | ||
| M9954 | Magainin II | Peptides |
| Magainin II is an antimicrobial peptide (AMP) isolated from the skin of the African clawed frog Xenopus laevis. | ||
| M10263 | Sodium hyaluronate | Others |
| Hyaluronic acid sodium | ||
| Sodium Hyaluronic is is an anionic, nonsulfated glycosaminoglycan distributed widely throughout connective, epithelial, and neural tissues, it is used as a humectant to increase moisture in the skin, it may also serve as an emulsifier. | ||
| M10941 | Tapinarof | Aryl hydrocarbon Receptor |
| WBI-1001; Benvitimod; GSK2894512 | ||
| Tapinarof (WBI-1001) is a Frist in class aromatic hydrocarbon receptor (AhR) agonist with EC50 of 13 nM. Tapinarof reduced skin inflammation in mice. It can effectively inhibit inflammatory cytokines, regulate skin barrier protein expression and antioxidant activity. | ||
| M11117 | Kukoamine B | Others |
| Kukoamine B is an active ingredient isolated from the skin of the earth bone, which has antioxidant, anti-acute inflammation and anti-diabetic activities. | ||
| M11129 | Dihydromorin | Tyrosinase |
| trans-Dihydromorin is an effective hypopigmenting agent in normal skin cells, hypopigmenting agents effective in melanoma system may not be effective on normal melanocytes, indicating that a non-tumor melanocyte system is more suitable for the screening of hypopigmenting agents. | ||
| M11484 | Cinobufotalin | Wnt/beta-catenin |
| Cinobufotalin is a cardiotonic steroid, or butadienolide, derived from the skin secretions of toads. SREBP1 is a novel inhibitor that inhibits the proliferation of hepatocellular carcinoma by targeting adipogenesis. | ||
| M13415 | Avarofloxacin | Others |
| JNJ-Q2 | ||
| Avarofloxacin (JNJ-Q2) is a broad-spectrum fluoroquinolone antibacterial compound used in the study of acute bacterial skin infections and acquired pneumonia. Avarofloxacin (JNJ-Q2) is an aminoethyl piperidine fluoroquinolone with an average MIC90 value of 0.12 mg/L. | ||
| M13601 | CDK9-IN-2 | CDK |
| CDK9-IN-2 is a special cyclin-dependent kinase 9 (CDK9) inhibitor, with IC50s of 5 nM and 7 nM in H929 multiple myeloma(MM) cell line (72 hours) and A2058 skin cell line (72 hours), respectively. | ||
| M13974 | Clobetasone butyrate | GCR |
| Clobetasone butyrate is a synthetic glucocorticoid and has topical anti-inflammatory activity especially in skin. Clobetasone butyrate can be used to relieve corticosteroid-responsive dermatoses, including atopic dermatitis and psoriasis. | ||
| M14083 | Paradol | COX |
| [6]-Gingerone; [6]-Paradol | ||
| Paradol is a pungent phenolic substance found in ginger and other Zingiberaceae plants. Paradol is an effective inhibitor of tumor promotion in mouse skin carcinogenesis, binds to cyclooxygenase (COX)-2 active site. | ||
| M14398 | Pentanoic acid | Metabolite/Endogenous Metabolite |
| Pentanoic acid, a short-chain fatty acid, is a product of bacterial metabolism and are associated with allergic skin disorders. Pentanoic acid activates ROCK signaling pathway. | ||
| M14417 | Urocanic acid | Metabolite/Endogenous Metabolite |
| Urocanic acid, produced in the upper layers of mammalian skin, is a major absorber of ultraviolet radiation (UVR). | ||
| M14544 | 4-Methylbenzylidene camphor | AChR/AChE |
| 4-MBC; Enzacamene | ||
| 4-Methylbenzylidene camphor(4-MBC; Enzacamene)is an organic camphor derivative that is used in the cosmetic industry for its ability to protect the skin against UV, specifically UV B radiation. | ||
| M14826 | SPACE peptide | Peptides |
| SPACE peptide is a skin penetrating peptide (SPPs). SPACE peptide can enhance topical delivery of a macromolecule, hyaluronic acid. | ||
| M19138 | Sanggenol L | p53 |
| Sanggenol L induces caspase-dependent and caspase-independent apoptosis in melanoma skin cancer cells. Sanggenol L induces of apoptosis via suppression of PI3K/Akt/mTOR signaling and cell cycle arrest via activation of p53 in p | ||
| M21218 | Sapienic acid sodium | Anti-infection |
| Sapienic acid sodium is a fatty acid commonly found on the skin and in mucosa. Sapienic acid sodium is active against Streptococcus sanguinis, Streptococcus mitis and Fusobacterium nucleatum with MBC values of 31.3 μg/mL, 375.0 μg/mL and 93.8 μg/mL, respectively. | ||
| M25163 | Barzolvolimab | c-Kit |
| CDX 0159 | ||
| Barzolvolimab (CDX 0159) is a humanized anti-KIT IgG1 monoclonal antibody. Barzolvolimab specificity and potently inhibits KIT activation by SCF. Barzolvolimab can reduce skin mast cells and disease activity in chronic inducible urticaria. | ||
| M25180 | Camoteskimab | IL Receptor/Related |
| AVTX-007; CERC-007; MEDI 2338 | ||
| Camoteskimab (AVTX-007) is a fully human, high-affinity anti-IL-18 monoclonal antibody. Camoteskimab has the potential for the autoinflammatory diseases research, including adult-onset Still’s disease (AOSD). | ||
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