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Methoxamine hydrochloride

Cat. No. M2842
Methoxamine hydrochloride Structure
Synonym:

Vasoxine HCl

Size Price Availability Quantity
Free Sample (0.5-1 mg)  USD 0 In stock
5mg USD 30  USD30 In stock
10mg USD 50  USD50 In stock
50mg USD 120  USD120 In stock
100mg USD 200  USD200 In stock
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Quality Control & Documentation
Biological Activity

Methoxamine is an α1-adrenergic receptor agonist, it induces vasoconstriction of skin and splanchnic blood vessels.

Chemical Information
Molecular Weight 247.72
Formula C11H17NO3.HCl
CAS Number 61-16-5
Solubility (25°C) DMSO ≥ 10 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] D Bell, et al. A randomised, controlled, crossover study to investigate the pharmacodynamics, pharmacokinetics and safety of 1R,2S-methoxamine hydrochloride (NRL001) in healthy elderly subjects

[2] J A D Simpson, et al. A randomised, controlled, crossover study to investigate the safety and response of 1R,2S-methoxamine hydrochloride (NRL001) on anal function in healthy volunteers

[3] W E SHECTOR, et al. Ventricular arrythmia induced by methoxamine hydrochloride

[4] L A CHOTKOWSKI, et al. Methoxamine hydrochloride in the treatment of paroxysmal supraventricular tachycardia; report of three cases

[5] C M Gibbs, et al. Methoxamine is an effective unconditioned stimulus for cardiovascular conditioning

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Keywords: Methoxamine hydrochloride, Vasoxine HCl supplier, Adrenergic Receptor, inhibitors, activators


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