Urocanic acid, produced in the upper layers of mammalian skin, is a major absorber of ultraviolet radiation (UVR).
| Molecular Weight | 138.12 |
| CAS Number | 104-98-3 |
| Solubility (25°C) | DMSO 50 mg/mL Water 2 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
[3] Prue H Hart, et al. The Multiple Roles of Urocanic Acid in Health and Disease
[4] M Norval, et al. Urocanic acid and immunosuppression
[5] S Gruner, et al. Cis-urocanic acid as a mediator of ultraviolet-light-induced immunosuppression
| Related Metabolite/Endogenous Metabolite Products |
|---|
| Isocitric acid trisodium salt
Isocitric acid trisodium salt is an endogenous metabolite. Isocitric acid trisodium salt is a substrate in the citric acid cycle. Isocitric acid trisodium salt can be used for the research of Alzheimer's Disease, Lewy Body Dementia and Anoxia. |
| Phytanic acid
Phytanic acid is an endogenous metabolite present in blood. |
| 2,3-Dihydroxyisovaleric acid
2,3-Dihydroxyisovaleric acid is a natural metabolite of the branched-chain amino acid leucine. It acts by activating the mTOR signaling pathway to promote the synthesis of new muscle proteins and reduce the breakdown of existing proteins. |
| Ursocholic acid
Ursocholic acid is a bile acid found predominantly in bile of mammals, which can be transformed into deoxycholic acid by the intestinal microflora in mice. |
| 5β-Cholanic acid
5β-Cholanic acid can be used for 5β-Cholanic acid derivatives synthesis. |
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