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IkB alpha (NFKBIA, IKBA) is a member of the NF-kappa-B inhibitor family that function to inhibit the NF-kB transcription factor. NFKBIA blocks the ability of NF-κB transcription factors to bind to DNA, which is required for NF-kB's proper functioning. Signal-induced degradation of I kappa B alpha exposes the nuclear localization signal of NF-kappa B, thus allowing it to translocate into the nucleus and activate transcription from responsive genes.
The recombinant human NFKBIA consisting of 323 amino acids and has a calculated molecular mass of 36.4 kDa. A DNA sequence encoding the human NFKBIA (NP_065390.1) (Phe 2-Leu 317) was expressed, with a polyhistide tag at the N-terminus.
Endotoxin < 1 EU/µg
Apparent Molecular Weight: 38 KDa, reducing conditions
Lyophilized from sterile 50mM Tris, 0.5M NaCl, pH 8.0.
| Form | Lyophilized powder |
| Solubility (25°C) | Reconstitute the lyophilized powder in distilled water up to 100 μg/ml. |
| Storage | Stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days and at -20°C for 3 months. |
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Products are for research use only. Not for human use. We do not sell to patients.
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